The optimization of essential oils supercritical CO2 extraction from Lavandula hybrida through static‑dynamic steps procedure and semi‑continuous technique using response surface method

Articles

Abstract
Pharmacognosy Research,2015,7,1,57-65.
Published:December 2014
Type:Original Article
Authors:
Author(s) affiliations:

Hossein Kamali1, Noushin Aminimoghadamfarouj1, Ebrahim Golmakani2, Alireza Nematollahi1

1Research Center of Natural Products Health, North Khorasan University of Medical Sciences, Bojnurd, Iran.

2Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

Abstract:

Aim: The aim of this study was to examine and evaluate crucial variables in essential oils extraction process from Lavandula hybrida through static‑dynamic and semi‑continuous techniques using response surface method. Materials and Methods: Essential oil components were extracted from Lavandula hybrida (Lavandin) flowers using supercritical carbon dioxide via static‑dynamic steps (SDS) procedure, and semi‑continuous (SC) technique. Results: Using response surface method the optimum extraction yield (4.768%) was obtained via SDS at 108.7 bar, 48.5°C, 120 min (static: 8×15), 24 min (dynamic: 8×3 min) in contrast to the 4.620% extraction yield for the SC at 111.6 bar, 49.2°C, 14 min (static), 121.1 min (dynamic). Conclusion: The results indicated that a substantial reduction (81.56%) solvent usage (kg CO2/g oil) is observed in the SDS method versus the conventional SC method.

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Schematic diagram of SFE system: (1) CO2 tank; (2) molecular sieve filter; (3) ss 2 µm pore size filter; (4) carbon dioxide transfer pump; (5, 8, 13) two-way needle valves; (6) Ethanol v; (7) high-pressure piston pump; (9) three ways valve; (10) preheating coil; (11) extraction cell; (12) thermostated oven; (14) back-pressure regulator; (15) sample collection vessel

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