Cytotoxic Essential Oil from Annona sengalensis Pers. Leaves

A L Ahmed,; S E M Bassemx; Y H Mohamed; MW Gamila

Cytotoxic Essential Oil from Annona sengalensis Pers. Leaves

Articles

Abstract

Pharmacognosy Research,2021,2,4,211-214.

DOI:10.4103/0974-8490.69105

Published:September 2010

Type:Original Article

Authors:

Author(s) affiliations:

A. L. Ahmed, S. E. M. Bassem¹, Y. H. Mohamed², M. W. Gamila

¹Department of Health Information Technology of Jeddah Community College, King Abdul-Aziz University, Al- Rehab, 80283 Jeddah, Kingdom of Saudi Arabia, 1Department Pharmacognosy, National Research Centre Dokki, 12622 Giza, Egypt,

²Department Pharmacognosy, Faculty of Pharmacy, Cairo University, Cairo, Egypt.

Abstract:

The cytotoxicity against brine shrimp of the essential oil obtained from the leaves of Annona senegalensis Pers. (Annonaceae) was studied. The confirmation of this toxicity has been done by using selected tumor cell lines (A549, HT29, MCF 7, RPMI, and U251). The results showed that the total oil and its fractions have showed mild to moderate cytotoxicity in brine shrimp lethality bioassay with LC50 = 27.3 μg/ml, and against some human tumor cell lines. The total oil and its fractions were analyzed by gas chromatography/mass spectroscopy (GC/MS). Seventy three compounds were identified.

Keywords:Annona senegalensis, Brine shrimp, cytotoxicity, Essential oil, GC/MS