Evaluation of extracts of leaf of three Ficus deltoidea varieties for antioxidant activities and secondary metabolites

Abdullah Zunoliza; Hussain Khalid; Ismail Zhari; Mat Ali Rasadah; Pisar Mazura; Jamaludin Fadzureena; Sahdan Rohana

Evaluation of extracts of leaf of three Ficus deltoidea varieties for antioxidant activities and secondary metabolites

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Abstract

Pharmacognosy Research,2009,1,4,216-223.

DOI:

Published:January 2010

Type:Original Article

Authors:

Author(s) affiliations:

Abdullah Zunoliza^a,*, Hussain Khalid^a, Ismail Zhari^a, Mat Ali Rasadah^b, Pisar Mazura^b, Jamaludin Fadzureena^b, Sahdan Rohana^b

^aSchool of Pharmaceutical Sciences, University Science of Malaysia, Minden Campus, 11800 Penang, MALAYSIA.

^bMedicinal Plants Division, Forest Research Institute Malaysia (FRIM), 52109 Kepong, Selangor, MALAYSIA.

Abstract:

Present study aimed to investigate alcoholic and aqueous extracts of three varieties of Ficus deltoidea for antioxidant activity using in vitro models such as free radical scavenging activity, reduction power of iron (III), superoxide anion (O₂-) scavenging, xanthine oxidase (XOD), nitric oxide (NO·) and lipid peroxidation. The total polyphenols, flavonoids and tannins were estimated using colorimetry in order to investigate their correlation with antioxidant activities. Alcoholic and aqueous extracts of different varieties of the plant exhibited different radical scavenging activities in different models (P<0.05). Both the types of extracts displayed high antioxidant activity in DPPH and superoxide anion scavenging models, and the activity was comparable to quercetin, rutin, butylated hydroxyanisole (BHA), ascorbic acid and allopurinol. A correlation was observed between antioxidant activity and content of total polyphenols, flavonoids and tannins. The results of this study indicate that the extracts of Ficus deltoidea possess promising antioxidant activity.

Keywords:Antioxidant, Ficus deltoidea, Flavonoids, Polyphenols, Tannins

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% antioxidant activity of standards, different extracts of leaves of three vareities Ficus deltoidea by DPPH model, FDT1M and FDT2M (methanol extracts of F. D. var. terengganuensis sample 1 and 2); FDT1W and FDT2W (aqueous extracts of F. D. var. terengganuensis sample 1 and 2); FDAM (F. D. var. Angustifolia methanol extract); FDAW (F. D. var. Angustifolia aqueous extract); FDDM (F. D. var. Deltoidea methanol extract). FDDW (F. D. var. Deltoidea aqueous extract; QTN (quercetin); BHA (butylated hydroxylanisole); Ac. acid (ascorbic acid); * significant difference of samples as compared to all the standards (P<0.05).

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