Secondary Metabolites and Bioactivities of Myrtus communis

Mahmoud I Nassar; El-Sayed A Aboutabl; Rania F Ahmed; Ezzel-Din A EL-Khrisy; Khaled M Ibrahim; Amany A Sleem

Secondary Metabolites and Bioactivities of Myrtus communis

Articles

Abstract

Pharmacognosy Research,2010,2,6,325-329.

DOI:10.4103/0974-8490.75449

Published:January 2011

Type:Original Article

Authors:

Author(s) affiliations:

Mahmoud I Nassar¹, El-Sayed A Aboutabl², Rania F Ahmed¹, Ezzel-Din A El-Khrisy¹, Khaled M Ibrahim², Amany A Sleem³

¹Department of Chemistry of Natural Compounds, National Research Centre, Dokki, Cairo, Egypt

²Department of Pharmacognosy, Faculty of Pharmacy, Cairo University, Cairo, Egypt

3Department of Pharmacology, National Research Centre, Dokki, Cairo, Egypt

Abstract:

Background: Myrtus species are characterized by the presence of phenolic acids, flavonoids, tannins, volatile oils and fatty acids. They are remedies for variety of ailments. This study therefore investigated medicinal effects of Myrtus communis L. Methods: Bioactivity studies of Myrtus communis L. leaves were carried out on volatile oil, 7% methanol and aqueous extracts and the isolated compounds myricetin 3-O-β-glucopyranoside, myricetin 3-O-∝-rhamnopyranoside and gallic acid. Results: Determination of the median lethal dose (LD 50 ) revealed that the volatile oil, alcoholic and aqueous extracts were practically nontoxic and highly safe as no lethality was observed. The tested materials (volatile oil, alcoholic and aqueous extracts, myricetin 3-O-β-glucopyranoside, myricetin 3-O-∝-rhamnopyranoside and gallic acid) showed significant antihyperglycemic, anti-inflammatory and antinociceptive effects as compared with control groups and reference drugs. Conclusion : Administration of extracts of M. communis leaves could be safe at the dose used in this study.