TY - JOUR T1 - Secondary Metabolites and Bioactivities of Myrtus communis JF - Pharmacognosy Research Y1 - 2010 A1 - Mahmoud I Nassar A1 - El-Sayed A Aboutabl A1 - Rania F Ahmed A1 - Ezzel-Din A EL-Khrisy A1 - Khaled M Ibrahim A1 - Amany A Sleem KW - Anti-inflammatory KW - Antihyperglycemic KW - Antinociceptive KW - LD 50 KW - Myrtus communis KW - Volatile oil AB -

Background: Myrtus species are characterized by the presence of phenolic acids, flavonoids, tannins, volatile oils and fatty acids. They are remedies for variety of ailments. This study therefore investigated medicinal effects of Myrtus communis L. Methods: Bioactivity studies of Myrtus communis L. leaves were carried out on volatile oil, 7% methanol and aqueous extracts and the isolated compounds myricetin 3-O-β-glucopyranoside, myricetin 3-O-∝-rhamnopyranoside and gallic acid. Results: Determination of the median lethal dose (LD 50 ) revealed that the volatile oil, alcoholic and aqueous extracts were practically nontoxic and highly safe as no lethality was observed. The tested materials (volatile oil, alcoholic and aqueous extracts, myricetin 3-O-β-glucopyranoside, myricetin 3-O-∝-rhamnopyranoside and gallic acid) showed significant antihyperglycemic, anti-inflammatory and antinociceptive effects as compared with control groups and reference drugs. Conclusion : Administration of extracts of M. communis leaves could be safe at the dose used in this study.

VL - 2 IS - 6 ER -