ArticlesAbstractPharmacognosy Research,2025,17,4,1214-1217.DOI:10.5530/pres.20252201Published:August 2025Type:Original ArticleAuthors:J. Priyadharisini, N. Savitha, and Lydia Jeeboi Paramel Author(s) affiliations:J. Priyadharisini1,*, N. Savitha2, Lydia Jeeboi Paramel2 1Department of Pharmaceutical Chemistry, School of Pharmacy Sri Balaji Vidyapeeth (Deemed to be University), PillayarKuppam, Pondicherry, INDIA. 2Department of Pharmaceutical Chemistry, Gautham College of Pharmacy, Sultanapalya, R.T Nagar post, Bangalore, Karnataka, INDIA. Abstract:Background: Garcinia cambogia fruit popularly specified as (Guttiferae) Clusiaceae has been used for variety of diseases. Depression is mental disorder which affects person day to day activities. Objectives: The main aim of this study is needed to assess the antidepressant activity of chloroform extract of Garcinia cambogia fruit using forced swim test in mice. Materials and Methods: Group I received control. Group 2 received standard drug Fluoxetine 20 mg/kg body weight. Group 3 and 4 received in doses 200 mg/kg and 400 mg /kg body weight of Garcinia cambogia fruit chloroform extract (P.O.) orally respectively. 60 min after the final dose of standard drug immobility period was recorded. Floating in water without swimming (immobility period) was recorded using a stopwatch. Results and Discussion: Garcinia cambogia chloroform extract at a concentration of 200 mg/kg and 400 mg/kg showed reduction in immobility period. In concentration of 400 mg/kg was found to exhibit significant antidepressant activity. Immobility period in seconds for 400 mg was found to be 187.8±1.7 when compared with control of 217±0.61. Conclusion: Reduction in immobility period is considered to have antidepressant effect on animal models. Therefore, chloroform extract of Garcinia cambogia indicates antidepressant potential. The outcome of the current study specify the Garcinia cambogia chloroform fruit extract contains xanthone as one phytochemical constituent which may be responsible to be functioning to show anti-depressant activity. Keywords:Fluoxetine, Forced swim test, Garcinia cambogia fruits, Immobility periodView:PDF (211.83 KB) PDF Thumbnails Document Outline Search Document Find Toggle Sidebar Previous Next Page: Fullscreen Print Download Current View Zoom Out Zoom In Automatic Zoom Actual Size Fit Page Full Width 50% 75% 100% 125% 150% 200% More Information Less Information Close Click here to download the PDF file. Images Effects of Garcinia cambogia fruit chloroform extracts and Fluoxetine on duration immobility period in seconds forced swim test. n=6, values expressed as mean±SEM, one way ANOVA followed by Dunett test ***p<0.001 when compared with the control group. Forced swim test table animals treated with 2 doses 200 mg and 400 mg P.O. showed decrease in their mobility time which was more significant in 400 mg. Decrease in mobility time was found to be 212.8±2.85, 187.8±1.7 for 200 mg and 400 mg p<0.001 respectively when compared with control 217±0.61.Standard drug fluoxetine .18±2.32 showed decrease in immobility KeywordsFluoxetineForced swim testGarcinia cambogia fruitsImmobility period ‹ Nephroprotective and Cytotoxic Assessment of Moringa concanensis Leaf Extract in Gentamicin-Induced Renal Injury in Rats up Evaluation of Neuroprotective Potential of Water-Dispersible Turmeric Extract and Sustained-Release Ashwagandha Root Extract against B[A]P Induced Neurotoxicity in Zebrafish ›