02356nas a2200205 4500008004100000245010400041210006900145260001600214300000800230490000700238520168600245653001501931653002101946653002901967653002201996100002302018700001602041700002702057856006602084 2025 eng d00aDiagram of the effect of different concentrations of S. khuzistanica on the viability of HT29 cells0 aDiagram of the effect of different concentrations of S khuzistan cAugust 2025 a1-40 v173 a

Background: Garcinia cambogia fruit popularly specified as (Guttiferae) Clusiaceae has been used for variety of diseases. Depression is mental disorder which affects person day to day activities. Objectives: The main aim of this study is needed to assess the antidepressant activity of chloroform extract of Garcinia cambogia fruit using forced swim test in mice. Materials and Methods: Group I received control. Group 2 received standard drug Fluoxetine 20 mg/kg body weight. Group 3 and 4 received in doses 200 mg/kg and 400 mg /kg body weight of Garcinia cambogia fruit chloroform extract (P.O.) orally respectively. 60 min after the final dose of standard drug immobility period was recorded. Floating in water without swimming (immobility period) was recorded using a stopwatch. Results and Discussion: Garcinia cambogia chloroform extract at a concentration of 200 mg/kg and 400 mg/kg showed reduction in immobility period. In concentration of 400 mg/kg was found to exhibit significant antidepressant activity. Immobility period in seconds for 400 mg was found to be 187.8±1.7 when compared with control of 217±0.61. Conclusion: Reduction in immobility period is considered to have antidepressant effect on animal models. Therefore, chloroform extract of Garcinia cambogia indicates antidepressant potential. The outcome of the current study specify the Garcinia cambogia chloroform fruit extract contains xanthone as one phytochemical constituent which may be responsible to be functioning to show anti-depressant activity.

10aFluoxetine10aForced swim test10aGarcinia cambogia fruits10aImmobility period1 aPriyadharisini, J.1 aSavitha, N.1 aParamel, Lydia, Jeeboi uhttps://www.phcogres.com/article/2025/17/4/105530pres20252201