Banisterine Alleviates Morphine‑based Nephrotoxicity by Antioxidant Property: An In vivo Study

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Abstract
Pharmacognosy Research,2020,12,2,137-142.
Published:May 2021
Type:Original Article
Authors:
Author(s) affiliations:

Mohammad Reza Salahshoor1, Cyrus Jalili2, Amir Abdolmaleki1, Shiva Roshankhah1

1Department of Anatomical Sciences, Medical School, Kermanshah University of Medical Sciences, Kermanshah, IRAN.

2Department of Anatomical Sciences, Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, IRAN.

Abstract:

Background: Banisterine (BAN) as an alkaloid agent has antioxidant properties. The morphine (MOR) with the character of free radical generation has an effective role on renal pathogenesis. Objectives: This investigation critically examines the effects of the BAN against MOR‑induced damage to the kidneys of rats. Materials and Methods: Sixty‑four male Wistar rats were randomly assorted into 8 groups (8 rats in each), including the saline (Sal), MOR, BAN (5, 10, 15 mg/kg) and MOR + BAN treatment groups. All experimental procedures were applied by intraperitoneal injection daily for 20 days. Whole investigated values consist of total animal weight, weight of kidney, morphological criteria of kidney, antioxidant capacity and serum nitrite oxide levels. Results: Intraperitoneally MOR application significantly increased the levels of renal Malondialdehyde (MDA), blood urea nitrogen (BUN), blood creatinine, and blood nitrite oxide and also reduced the glomerular number and tissue ferric reducing/antioxidant power (FRAP) level compared to the Sal control group (P < 0.05). Treatment of BAN and BAN + MOR in all doses significantly reduced the levels of BUN, MDA, creatinine, glomerular diameter, and nitrite oxide and also increased the glomerular number and tissue FRAP levels compared to the MOR group (P < 0.05). Conclusion: The findings support the idea that the BAN with its antioxidant nature can eliminate MOR renal toxicity.

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Effect of MOR, BAN, and BAN + MOR on weight of (a) kidney; (b) animals

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