ArticlesAbstractPharmacognosy Research,2009,1,1,1-3.Published:January 2010 Type:Original ArticleAuthors:M.P. Mazura, and S.K. Ling Author(s) affiliations:MP Mazura, SK Ling Medicinal Plants Programme, Forest Biotechnology Division, Forest Research Institute Malaysia, 52109 Kepong, Selangor, MALAYSIA. Abstract:A potential source for new lipoxygenase inhibitors is undoubtedly provided by the abundance of medicinal plants used in traditional medicine. As part of screening programme for biologically active plants, 20 extracts of different parts of 10 Malaysian medicinal plants belonging to four families were evaluated for their inhibitory activity on soybean 15-lipoxygenase (15-sLo). The leaves of Peronema canescens Jack. (Verbenaceae) were shown to be the most potent inhibitor with an IC50 value of 25.64 ,g/ml. While the extracts of P. canescens stem and Stereospermum fibricatum DC. (Bignonaceae) leaves were found to possess profound inhibitory activity with IC50 values of 33.65 and 39.41 ,g/ml, respectively. The methanol extracts obtained from Stenolobium stans (L.) D. Don (Bignonaceae) leaves and stems, Piper ribesioides Wall. (Piperaceae) stems and S. fibricatum stems were moderately active with IC50 values ranging from 40 to 60 ,g/ml. While the remaining samples showed low lipoxygenase inhibitory activity at concentration of 100 ,g/ml. Keywords:15-lipoxygenase inhibitory activity, Malaysian medicinal plants, Methanolic extractsView:PDF (278.2 KB) PDF Thumbnails Document Outline Search Document Find Toggle Sidebar Previous Next Page: Fullscreen Print Download Current View Zoom Out Zoom In Automatic Zoom Actual Size Fit Page Full Width 50% 75% 100% 125% 150% 200% More Information Less Information Close Click here to download the PDF file. Images Preliminary Studies on Lipoxygenase Inhibitory Activity of Selected Malaysian Medicinal Plants Keywords15-lipoxygenase inhibitory activityMalaysian medicinal plantsMethanolic extracts ‹ Pharmacognosy Research, Vol 1, Issue 1, Jan-Mar, 2009 up Diuretic activity of Sri Lankan black tea (Camellia sinensis L.) in rats ›