In vitro H + -K + ATPase Inhibitory Potential of Methanolic Extract of Cissus Quadrangularis Linn.

Priyanka Yadav; Aditya Ganeshpurkar; Gopal Rai

In vitro H + -K + ATPase Inhibitory Potential of Methanolic Extract of Cissus Quadrangularis Linn.

Articles

Abstract

Pharmacognosy Research,2012,4,2,123-126.

DOI:10.4103/0974-8490.94738

Published:april,2012

Type:Short Communication

Authors:

Author(s) affiliations:

Priyanka Yadav¹, Aditya Ganeshpurkar¹, Gopal Rai²

¹Department of Pharmacology, Shri Ram Institute of Technology -Pharmacy, Jabalpur, Madhya Pradesh, India.

²Department of Pharmacy, Guru Ramdas Khalsa Institute of Science and Technology, Jabalpur, Madhya Pradesh, India.

Abstract:

Objective: This study was undertaken to study in vitro H + -K + ATPase inhibitory potential of methanolic extract of Cissus quadrangularis Linn. Materials and Methods: Total phenolic and flavonoid contents from extract was quantified and H + -K + ATPase inhibition assay was performed in presence of different concentrations of standard (omeprazole) and methanol extract. Results: Extract showed significant (*P < 0.05) proton pump inhibitory activity in the goat gastric mucosal homogenate which was comparable to standard. Conclusions: These findings showed that methanolic extract of C. quadrangularis Linn. is potent inhibitor of proton pump.

Keywords:Cissus quadrangularis Linn., H+-K+ ATPase inhibition assay, in vitro.