A New Cytotoxic Ceramide from Dalbergia boehmii Taub. Stem Bark

Jean Pierre Abdou; Jean Noël Nyemb; Jean Momeni; Atikou Fadimatou; Abel Joël Yaya Gbaweng; Jean Paul Tsopmejio; Guidawa Fawa; Muhammad I. Choudhary

A New Cytotoxic Ceramide from Dalbergia boehmii Taub. Stem Bark

Articles

Abstract

Pharmacognosy Research,2022,14,4,442-445.

DOI:10.5530/pres.14.4.64

Published:October 2022

Type:Original Article

Authors:

Author(s) affiliations:

Jean Pierre Abdou^1,2, Jean Noël Nyemb^3,*, Jean Momeni¹, Atikou Fadimatou¹, Abel Joël Yaya Gbaweng¹, Jean Paul Tsopmejio⁴, Guidawa Fawa⁵, Muhammad I. Choudhary⁶

¹Department of Chemistry, Faculty of Science, University of Ngaoundere, Ngaoundere 454, CAMEROON.

²Centre for Research on Medicinal Plants and Traditional Medicine, Institute of Medical Research and Medicinal Plants Studies, Yaounde, CAMEROON.

³Department of Refining and Petrochemistry, National Advanced School of Mines and Petroleum Industries, University of Maroua, Kaele, CAMEROON.

⁴Department of Organic Chemistry, Faculty of Science, University of Yaounde 1, Yaounde, CAMEROON.

⁵Department of Biological Science, Faculty of Science, University of Ngaoundere, Ngaoundere, CAMEROON.

⁶H. E. J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences (ICCBS), University of Karachi, Karachi, PAKISTAN.

Abstract:

Background: Dalbergia boehmii (Leguminosae), is a medicinal plant used in the Northen part of Cameroon, against digestive tract diseases and fever. Objectives: This work which is part of the search for bioactive molecules through natural products, aimed to isolate, characterize and evaluate the cytotoxicity of compounds from D. boehmii. Materials and Methods: Chemical investigations were carrying out on stem barks of Dalbergia boehmii using chromatographic techniques. Structures elucidation of isolated compounds were done using 1D and 2D NMR as well as EI-MS and literature data. Some isolated compounds were evaluated in vitro against MCF-7 cell lines for their cytotoxicity activity, using the MTT colorimetric method. Results: The chemical investigation leaded to the isolation of a new ceramide derivative named Dalbergiamide (1), a triterpene identified as olean-12-ene-3,11-dione (2) isolated here for the first time from Dalbergia genus, along with two known compounds, glucoside 3-O-β- D-sitosterol (3) and glucoside 3-O-β-D-stigmasterol (4). Compounds 1 and 2 were found to be cytotoxic at 50 μM with IC50 value of 17.13 μM and 35.52 ± 2.95 μM respectively. Conclusion: These promising results suggested more in-depth studies should be carried out on this plant in order to assess its potential in the fight against cancer