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Anti-nephrotoxic activity of some medicinal plants from tribal rich pockets of Odisha

1, 2, 3★★ Corresponding author

  1. 1K.V. Virani Institute of Pharmacy and Research Centre, Badhada, Savarkundla, Gujarat
  2. 2College of Pharmaceutical Sciences, Bidyaniketan, Balighat, Puri
  3. 3University Department of Pharmaceutical Sciences, Utkal University, Vani Vihar, Bhubaneswar, Odisha, India

CORRESPONDENCE

Sabuj Sahoo

University Department of Pharmaceutical Sciences, Utkal University, Vani Vihar, Bhubaneswar, Odisha, India

sabujbiotech@rediffmail.com

Volume 6, Issue 3 · pp. 210-217 · 2014 · DOI: 10.4103/0974-8490.132598

ABSTRACT

Gentamicin, a strong cationic drug accumulated at biological membranes causes net increase in oxidative stress and lipid peroxidation leading to necrotic changes in renal tubles and consequently precipitates acute nephrotoxicity. Several phytoconstituents and plants extracts demonstrated significant anti-oxidant and cyto-protective activities. Vitex negundo Linn. (VN), Oroxylum indicum Vent. (OI) and Barringtonia acutangula Linn. (BA) are widely found throughout the Asian sub-continent including India, used extensively in different forms of Indian traditional medicine like Ayurveda and Unani. Nephroprotective activity of extracts of VN roots, OI whole plant and BA leaves were investigated against experimentally induced acute nephrotoxicity [Gentamicin (i.p; 80mg/kg for 7 days)] in Wistar rats as test animals. The rats were treated with Cystone (5 mL/kg; p.o) taken as positive control and methanol-dichloromethane (1:1) extracts of VN, OI and BA (200 mg/kg; p.o) as test drugs for 7 days. Following the said treatments, biochemical parameters of urine (volume, creatinine and lactate dehydrogenase (LDH)) and serum (urea, creatinine, albumin and total protein) were estimated. Renal anti-oxidant markers viz., superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) and lipid peroxidation (LPO) in renal tissue were assayed. Tissue sections of kidneys from different groups were made and histopathological features were observed. The extracts of VN, OI and BA significantly attenuated the nephrotoxicity by elevation of body weight, CAT, GPx and SOD or lowering urine LDH and creatinine, serum urea; serum creatinine and LPO respectively. Histopathological score of VN, OI and BA treated groups were 1+, 2+ and 2+ respectively against 4+ of the toxic group. The findings suggested the significant nephroprotection of VN roots followed by OI whole plant and BA leaves.

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    Mishra, S., Pani, S. R., & Sahoo, S. (2014). Anti-nephrotoxic activity of some medicinal plants from tribal rich pockets of Odisha. Pharmacognosy Research, 6(3), 210-217. https://doi.org/10.4103/0974-8490.132598

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    © 2014 Author(s)

    This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. CC BY-NC-SA 4.0