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Anti-diarrhoeal investigation from aqueous extract of Cuminum cyminum Linn. Seed in Albino rats

1, 2, 3, 4, 5★★ Corresponding author

  1. 1Departments of Pharmacology and Experimental Biology, Vedica College of Pharmacy, RKDF University, Bhopal, Madhya Pradesh
  2. 2Departments of Pharmaceutical Chemistry, Sri Sivani College of Pharmacy, Srikakulam
  3. 3Jayamukhi Institute of Pharmaceutical Science, Warangal, Andhra Pradesh
  4. 4Departments of Pharmacognosy and Phytochemistry, Sri Satya Sai Institute of Pharmaceutical Sciences
  5. 5Vedica College of Pharmacy, RKDF University, Bhopal, Madhya Pradesh, India

CORRESPONDENCE

Mohan Lal Kori

Vedica College of Pharmacy, RKDF University, Bhopal, Madhya Pradesh, India

mohanlalkori@gmail.com

Volume 6, Issue 3 · pp. 204-209 · 2014 · DOI: 10.4103/0974-8490.132596

ABSTRACT

Cuminum cyminum Linn. (Umbelliferae), commonly known as Jeera. It is native from mediterranean region, but today widely cultivated in Asian countries. It has been reported to possess various medicinal properties and an important food ingredient. The seed of the plant are claimed for treatment of diarrhoea by various traditional practitioners. Hence, the present investigation was undertaken to evaluate aq. extract of C. cyminum seeds (ACCS) against diarrhoea on albino rats. The animals were divided into five groups and the control group was applied with 2% acacia suspension, the standard group with loperamide (3 mg/kg) or atropine sulphate (5mg/kg) and three test groups administered orally with 100, 250 and 500 mg/kg of ACCS. The antidiarrhoeal effect was investigated by castor oil induce diarrhoea model, prostaglandin E2 (PGE2) induced enteropooling model, intestinal transit by charcoal meal test. The ACCS showed significant (P < 0.001) inhibition in frequency of diarrhoea, defecation time delaying, secretion of intestinal fluid as well as intestinal propulsion as compared to control and the graded doses of tested extract followed dose dependent protection against diarrhoea. The study reveals that the ACCS is a potent antidiarrhoeal drug which supports the traditional claim.

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    Sahoo, H. B., Sahoo, S. K., Sarangi, S. P., Sagar, R., & Kori, M. L. (2014). Anti-diarrhoeal investigation from aqueous extract of Cuminum cyminum Linn. Seed in Albino rats. Pharmacognosy Research, 6(3), 204-209. https://doi.org/10.4103/0974-8490.132596

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    © 2014 Author(s)

    This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. CC BY-NC-SA 4.0