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Ameliorative effect of Matricaria chamomilla.L on paraquat: Induced oxidative damage in lung rats

1★, 2, 2, 3, 4, 4★ Corresponding author

  1. 1Department of Toxicology and Pharmacology, School of Pharmacy, Hamadan University of Medical Sciences
  2. 2Biology, Laboratory of Plant Cell Biology
  3. 3Department of Chemistry, Bu-Ali Sina University
  4. 4Biochemistry, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran

CORRESPONDENCE

Akram Ranjbar

Department of Toxicology and Pharmacology, School of Pharmacy, Hamadan University of Medical Sciences

akranjbar1389@yahoo.com

Volume 6, Issue 3 · pp. 199-203 · 2014 · DOI: 10.4103/0974-8490.132595

ABSTRACT

Herbal medicines have been long used for antioxidant properties. The purpose of this study was to investigate the effect of hydroalcholic extract Matricaria chamomilla. L (M. chamomilla) against Paraquat (PQ) induced pulmonary injury in association with its antioxidant activity. Effective doses of PQ (5 mg/kg/day) and M. chamomilla (50 mg/kg/day) were administered alone or in combination for 7 days. At the end of the experiment, lung tissue of the animals was separated. The activity of enzymatic scavengers such as glutathione peroxidase (GPx) and superoxide dismutase (SOD), lipid peroxidation (LPO) and total antioxidant power (TAP) were measured. In these samples, the LPO, SOD, and GPx were higher in the PQ group as compared with controls. M. chamomilla extract ameliorated LPO, SOD, GPx and increased TAP in plasma and lung tissue of PQ induced changes. Co administration of PQ with M. chamomilla improved LPO and SOD, and GPx. M. chamomilla as natural antioxidant may be considered beneficial for the protection oxidative lung injury in PQ poisoning.

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    Ranjbar, A., Mohsenzadeh, F., Chehregani, A., Khajavi, F., Zijoud, S. H., & Ghasemi, H. (2014). Ameliorative effect of Matricaria chamomilla.L on paraquat: Induced oxidative damage in lung rats. Pharmacognosy Research, 6(3), 199-203. https://doi.org/10.4103/0974-8490.132595

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    © 2014 Author(s)

    This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. CC BY-NC-SA 4.0