Pharmacognosy Research logo
Submit
Pharmacognosy ResearchACADEMIC PUBLISHING
Article

Evaluation of in vitro Anti-Inflammatory Activity of Trichosanthes palmata against the Denaturation of Protein

1★, 1, 1, 1, 1, 1★ Corresponding author

  1. 1Department of Pharmacognosy, Pravara Rural College of Pharmacy, Pravaranagar, Loni, Maharashtra, INDIA.

CORRESPONDENCE

Arshu Pirmhommad Patel

Department of Pharmacognosy, Pravara Rural College of Pharmacy, Pravaranagar, Loni, Maharashtra, INDIA.

arshupatel59@gmail.com

Received: 08-11-2024; Accepted: 03-04-2025.

Volume 17, Issue 2 · pp. 654-658 · 2025 · DOI: 10.5530/pres.20252089

ABSTRACT

Trichosanthes palmata Lour. (Cucurbitaceae) is one of the important medicinal plants used traditionally for the treatment of asthma, earache, ophthalmia, leprosy, fever as well as used in the treatment of migraine. To validate folk used of Trichosanthes palmata as anti-inflammatory remedy. The leaves of Trichosanthes palmata were used for successive extraction (Maceration) with increasing polarity solvents. Ethanolic extract was selected for anti-inflammatory activity. In vitro anti-inflammatory activity was evaluated using protein denaturation method at different concentrations. Diclofenac sodium was used as standard drug. To evaluate the in vitro anti-inflammatory effect of ethanolic extract of leaves of Trichosanthes palmata against the denaturation of protein. Inhibition of protein denaturation method was evaluated for anti-inflammatory activity. The ethanolic extract of Trichosanthes palmata exhibited anti-inflammatory activity by protein denaturation method. The ethanolic extract from Trichosanthes palmata leaves exhibited significantly enhanced anti-inflammatory activity with increasing concentrations. This effect is likely attributed to the presence of active phytocompounds, including flavonoids, triterpenoids and related polyphenols. Consequently, Trichosanthes palmata holds potential as an anti-inflammatory agent.

KEYWORDS

Open in new tab

REFERENCES

As published

Showing references and in-text citations exactly as published.

    Cite this article

    SELECT FORMAT

    Patel, A. P., Dhavan, S. P., Shinde, T. R., Sonawane, M. D., Patel, H. A., & Wani, N. M. (2025). Evaluation of in vitro Anti-Inflammatory Activity of Trichosanthes palmata against the Denaturation of Protein. Pharmacognosy Research, 17(2), 654-658. https://doi.org/10.5530/pres.20252089

    Copyright and licence

    © 2025 Author(s)

    This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. CC BY-NC-SA 4.0