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Effect of licorice versus bismuth on eradication of Helicobacter pylori in patients with peptic ulcer disease

1, 1★, 1, 2, 3★ Corresponding author

  1. 1Department of Internal Medicine, Medical Plant Research Center
  2. 2Social Health Determinants Research Center, School of Health
  3. 3Department of Epidemiology and Biostatistics, Clinical Biochemistry Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran

CORRESPONDENCE

Ghorbanali Rahimian

Department of Internal Medicine, Medical Plant Research Center

dr_rahimian29638@yahoo.com

Volume 6, Issue 4 · pp. 341-344 · 2014 · DOI: 10.4103/0974-8490.138289

ABSTRACT

Different therapeutic regimens were used for eradication of Helicobacter pylori, based on the cost, effectiveness and patient’s compliance. The aim of this study was the evaluation of licorice compared with bismuth in quadruple regimen on eradication of H. pylori in patients with peptic ulcer disease (PUD). In a double-blind clinical trial study, 60 patients with PUD and positive rapid urease test were enrolled. The patients were randomly allocated into two equal groups. In first group, licorice, amoxicillin, metronidazole and omeprazole and in the second (control) group, bismuth subsalicylate, amoxicillin, metronidazole and omeprazole were prescribed respectively, and 4 weeks after treatment, in order to evaluate H. pylori eradication, urea breath test was done in all patients. The outcome of the study was the preference usage of licorice as an effective medication for H. pylori eradication. Mean age of the patients in the control and case groups were 40.8 ± 15.5 and 42.2 ± 15.8 years, respectively (P = 0.726). Seventeen (56.7%) patients in control group and 16 (53.3%) in the case group were female (P = 0.795). Both groups were similar based on frequency of gastric or duodenal ulcer. Response to treatment were seen in 20 (67%) and 17 (57%) patients of case and control groups, respectively (P > 0.05). Our study showed that licorice is as effective as bismuth in H. pylori eradication; therefore, in patients whom bismuth is contraindicated, licorice can be used safely instead.

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    Momeni, A., Rahimian, G., Kiasi, A., Amiri, M., & Kheiri, S. (2014). Effect of licorice versus bismuth on eradication of Helicobacter pylori in patients with peptic ulcer disease. Pharmacognosy Research, 6(4), 341-344. https://doi.org/10.4103/0974-8490.138289

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    © 2014 Author(s)

    This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. CC BY-NC-SA 4.0