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Brine shrimp lethality and acute oral toxicity studies on Swietenia mahagoni (Linn.) Jacq. seed methanolic extract

1, 1, 2★, 1, 1, 1★ Corresponding author

  1. 1Center for Drug Research and
  2. 2Institute for Research in Molecular Medicine, Universiti Sains Malaysia 11800 Penang, Malaysia

CORRESPONDENCE

Sreenivasan Sasidharan

Institute for Research in Molecular Medicine, Universiti Sains Malaysia, 11800 Penang, Malaysia

srisasidharan@yahoo.com

Received: 19-01-2010; Accepted: 07-09-2010.

Volume 2, Issue 4 · pp. 215-220 · 2010 · DOI: 10.4103/0974-8490.69107

ABSTRACT

The seeds of Swietenia mahagoni have been applied in folk medicine for the treatment of hypertension, diabetes, malaria, amoebiasis, cough, chest pain, and intestinal parasitism. Here we are the first to report on the toxicity of the Swietenia mahagoni crude methanolic (SMCM) seed extract. SMCM seed extract has been studied for its brine shrimp lethality and acute oral toxicity, in mice. The brine shrimp lethality bioassay shows a moderate cytotoxicity at high concentration. The LC50 for the extract is 0.68 mg/ml at 24 hours of exposure. The LD50 of the SMCM seed extract for acute oral toxicity in mice is greater than 5000 mg/kg. This study demonstrates that Swietenia mahagoni crude methanolic seed extract may contain bioactive compounds of potential therapeutic significance which are relatively safe from toxic effects, and can compromise the medicinal use of this plant in folk medicine.

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    Sahgal, G., Ramanathan, S., Sasidharan, S., Mordi, M. N., Ismail, S., & Mansor, S. M. (2010). Brine shrimp lethality and acute oral toxicity studies on Swietenia mahagoni (Linn.) Jacq. seed methanolic extract. Pharmacognosy Research, 2(4), 215-220. https://doi.org/10.4103/0974-8490.69107

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    © 2010 Author(s)

    This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. CC BY-NC-SA 4.0