Article · Volume 14, Issue 4 · pp. 442-445
A New Cytotoxic Ceramide from Dalbergia boehmii Taub. Stem Bark Articles
Jean Pierre Abdou1, Jean Noël Nyemb2, Jean Momeni3, Atikou Fadimatou3, Abel Joël Yaya Gbaweng3, Jean Paul Tsopmejio4, Guidawa Fawa5, Muhammad I. Choudhary6
- 1Department of Chemistry, Faculty of Science, University of Ngaoundere, Ngaoundere 454, CAMEROON., 2Centre for Research on Medicinal Plants and Traditional Medicine, Institute of Medical Research and Medicinal Plants Studies, Yaounde, CAMEROON.
- 2Department of Refining and Petrochemistry, National Advanced School of Mines and Petroleum Industries, University of Maroua, Kaele, CAMEROON.
- 3Department of Chemistry, Faculty of Science, University of Ngaoundere, Ngaoundere 454, CAMEROON.
- 4Department of Organic Chemistry, Faculty of Science, University of Yaounde 1, Yaounde, CAMEROON.
- 5Department of Biological Science, Faculty of Science, University of Ngaoundere, Ngaoundere, CAMEROON.
- 6H. E. J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences (ICCBS), University of Karachi, Karachi, PAKISTAN.
Abstract
Background: Dalbergia boehmii (Leguminosae), is a medicinal plant used in the Northen part of Cameroon, against digestive tract diseases and fever.Objectives: This work which is part of the search for bioactive molecules through natural products, aimed to isolate, characterize and evaluate the cytotoxicity of compounds from D. boehmii.Materials and Methods: Chemical investigations were carrying out on stem barks of Dalbergia boehmii using chromatographic techniques. Structures elucidation of isolated compounds were done using 1D and 2D NMR as well as EI-MS and literature data. Some isolated compounds were evaluated in vitro against MCF-7 cell lines for their cytotoxicity activity, using the MTT colorimetric method.Results: The chemical investigation leaded to the isolation of a new ceramide derivative named Dalbergiamide (1), a triterpene identified as olean-12-ene-3,11-dione (2) isolated here for the first time from Dalbergia genus, along with two known compounds, glucoside 3-O-β- D-sitosterol (3) and glucoside 3-O-β-D-stigmasterol (4). Compounds 1 and 2 were found to be cytotoxic at 50 μM with IC50 value of 17.13 μM and 35.52 ± 2.95 μM respectively.Conclusion: These promising results suggested more in-depth studies should be carried out on this plant in order to assess its potential in the fight against cancer.
Keywords: cytotoxicity; Dalbergia boehmii; MCF-7; Natural Products
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