Pharmacognosy Research logo
Submit
Pharmacognosy ResearchACADEMIC PUBLISHING
Back

PR · Lens · Cytotoxic acetogenins from Annona glabra cultivated in Egypt

PDF

Article · Volume 1, Issue 3 · pp. 130-135

Cytotoxic acetogenins from Annona glabra cultivated in Egypt

Ahmed Abdel-lateff1, Bassem S. El-Menshawi2, Mohamed Y. Haggag3, Mahmoud A. Nawwar4

  1. 1Pharmacognosy Department, Faculty of Pharmacy, Minia University, 61519 Minia, Egypt.
  2. 2Pharmacognosy Department, National Research Centre Dokki, 12622 Giza, Egypt.
  3. 3Pharmacognosy Department, Faculty of Pharmacy, Cairo University, Cairo, Egypt.
  4. 4Tanning and Protein Department, National Research Centre Dokki, Giza Egypt.

Abstract

Bio-assay guided fraction of the methanolic extract of Annona glabra seeds (Annonaceae), cultivated in Egypt, revealed to the isolation of three bis-tetrahydrofuran acetogenins; squamocin-C (1), squamocin-D (2), and annonin I (3). Compounds 1 and 2 were obtained as stereoisomeric mixture. All isolates were assayed for their cytotoxicity twards brine shrimp and five in vitro cancer cell lines (A549, HT29, MCF 7, RPMI, and U251), and showed significant activity The structures of all compounds were determined by interpretation of their NMR and MS analyses.

Keywords: Annona glabra; Annonaceae; Acetogenin; Cytotoxic; Brine shrimp

The full text of this article, with its figures and tables, is its PDF, shown below. Open the PDF in a new tab.