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Cytotoxic acetogenins from Annona glabra cultivated in Egypt

1, 2, 3, 4

  1. 1Pharmacognosy Department, Faculty of Pharmacy, Minia University, 61519 Minia, Egypt.
  2. 2Pharmacognosy Department, National Research Centre Dokki, 12622 Giza, Egypt.
  3. 3Pharmacognosy Department, Faculty of Pharmacy, Cairo University, Cairo, Egypt.
  4. 4Tanning and Protein Department, National Research Centre Dokki, Giza Egypt.

CORRESPONDENCE

Ahmed Abdel-lateff

Pharmacognosy Department, Faculty of Pharmacy, Minia University, 61519 Minia, Egypt.

aabelazim@yahoo.co.uk

Received: 10-03-2009; Accepted: 09-04-2009.

Volume 1, Issue 3 · pp. 130-135 · 2009 · DOI:

ABSTRACT

Bio-assay guided fraction of the methanolic extract of Annona glabra seeds (Annonaceae), cultivated in Egypt, revealed to the isolation of three bis-tetrahydrofuran acetogenins; squamocin-C (1), squamocin-D (2), and annonin I (3). Compounds 1 and 2 were obtained as stereoisomeric mixture. All isolates were assayed for their cytotoxicity twards brine shrimp and five in vitro cancer cell lines (A549, HT29, MCF 7, RPMI, and U251), and showed significant activity The structures of all compounds were determined by interpretation of their NMR and MS analyses.

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    Abdel-lateff, A., El-Menshawi, B. S., Haggag, M. Y., & Nawwar, M. A. (2009). Cytotoxic acetogenins from Annona glabra cultivated in Egypt. Pharmacognosy Research, 1(3), 130-135.

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    © 2009 Author(s)

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