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Antifouling Alkaloids from Crinum augustum (Amaryllidaceae)

1, 1, 1, 2, 2, 3, 4

  1. 1Pharmacognosy Department, Faculty of Pharmacy, Minia University, Minia, Egypt.
  2. 2Pharmacognosy Department, Faculty of Pharmacy, Assiut University, Egypt.
  3. 3Faculty of environmental earth science, Hokkaido University, Sapporo, Japan.
  4. 4Central Research Institute of Electric Power Industry, Biology Department, Abiko, Chiba, Japan.

CORRESPONDENCE

Ahmed Abdel-Lateff

Pharmacognosy Department, Faculty of Pharmacy, Minia University, 61519 Minia, Egypt.

aabelazim@yahoo.co.uk

Received: 02-01-2009; Accepted: 22-06-2009.

Volume 1, Issue 2 · pp. 43-52 · 2009 · DOI:

ABSTRACT

Fractionation and purification of the ethanolic extract of the bulbs of Crinum augustum Rox. (Amaryllidaceae) cultivated in Egypt yielded five alkaloids 6-methoxy-crinamine (1), crinamine (2), buphanisine (3), ungeremine (4), and hippadine (5); two fatty acid derivatives: myristic acid ethyl ester (6) and palmitic acid ethyl ester (7); four terpenoidal and steroidal compounds: ursolic acid (8), β-sitosterol-O- β glucopyranoside (9) and mixture of β- sitosterol (10) and stigmasterol (11). The structures of all compounds were determined by interpretation of their spectroscopic data; 1D (1H and 13C), 2D (HSQC, COSY, DQF, NOE and HMBC) NMR; MS and UV analyses. The compounds (1-4) and (6-8) were tested towards biofouling activity using larvae of barnacle Balance amphitrie. Significant activities of 1, 2 and 3 with EC50 1.8, 1.2 and 0.75 µg/mL respectively, were observed.

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    Refaat, J., Abdel-Lateff, A., Kamel, M. S., Ali, A. A., Ramadan, M. A., Okino, T., & Nogata, Y. (2009). Antifouling Alkaloids from Crinum augustum (Amaryllidaceae). Pharmacognosy Research, 1(2), 43-52.

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    © 2009 Author(s)

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