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Anti-Leishmania Activity of Osthole

1★, 1, 2, 3, 2, 2★ Corresponding author

  1. 1Department of Pharmacognosy, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan
  2. 2Department of Medical Parasitology and Mycology, School of Medicine, Isfahan University of Medical Sciences, Isfahan
  3. 3Department of Medical Parasitology, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

CORRESPONDENCE

Elaheh Kordzadeh Kermani

Department of Pharmacognosy, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan

kordzadeh.elahe@gmail.com

Volume 8, Issue 5s · pp. S1-S4 · 2016 · DOI: 10.4103/0974-8490.178650

ABSTRACT

Treatment of cutaneous leishmaniasis (CL) is occasionally highly resistant to pentavalent antimonials, the gold standard in pharmacotherapy of CL. Since there is no effective vaccine, the discovery of natural antileishmanial products as complementary therapeutic agents could be used to improve the current regimens. In this study in~vitro and in~vivo antileishmanial activities of osthole, a natural coumarin known to possess antibacterial and parasiticidal activities are evaluated. Leishmania major infected J774.A1 macrophages were treated with increasing concentrations of osthole. CL lesions of BALB/c mice were treated topically with 0.2% osthole. Osthole exhibited dose-dependent leishmanicidal activity against intracellular amastigotes with IC50 value of 14.95 mg/ml. Treatment of CL lesions in BALB/c mice with osthole significantly declined lesion progression compared to untreated mice (P < 0.05), however did not result in recovery. Osthole demonstrated remarkable leishmanicidal activity in~ vitro. Higher concentrations of osthole may demonstrate the therapeutic property in~vivo.

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    Kermani, E. K., Sajjadi, S. E., Hejazi, S. H., Arjmand, R., Saberi, S., & Eskandarian, A. A. (2016). Anti-Leishmania Activity of Osthole. Pharmacognosy Research, 8(5s), S1-S4. https://doi.org/10.4103/0974-8490.178650

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    © 2016 Author(s)

    This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. CC BY-NC-SA 4.0