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Chemopreventive effect of methanolic extract of Azadirachta indica on experimental Trypanosoma brucei induced oxidative stress in dogs

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  1. 0Departments of Veterinary Medicine and Physiology, Biochemistry and Pharmacology, University of Ibadan, Ibadan, Nigeria

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Temidayo O. Omobowale

Departments of Veterinary Medicine and Physiology, Biochemistry and Pharmacology, University of Ibadan, Ibadan, Nigeria

bukitayo_omobowale@yahoo.com

Volume 7, Issue 3 · pp. 249-258 · 2015 · DOI: 10.4103/0974-8490.157972

ABSTRACT

The medicinal properties of Azadirachta indica have been harnessed for many years in the treatment of many diseases in both humans and animals. Twenty-five apparently healthy dogs weighing between 3 and 8 kg were randomly divided into five groups with five dogs in each group. Ameliorative effect of A. indica on erythrocyte antioxidant status and markers of oxidative stress were assessed. Liver and kidney function tests were also performed. Pre-treatment with methanolic extract of Azadirachta indica (MEAI) at different doses did not significantly alter the values of alanine aminotransferase, aspartate aminotransferase and alkaline phosphatase activity in Trypanosoma brucei infection. Although, serum creatinine significantly (P 0.05) difference compared to the values obtained in pre-treated animals. Pre-treatment with 100 mg/kg and 200 mg/kg of A. indica significantly (P < 0.05) decreased serum myeloperoxidase activity at 2 weeks post-infection with T. brucei. From this study, MEAI showed significant ability to attenuate oxidative stress and inflammation during experimental T. brucei infection.

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    Omobowale, T. O., Oyagbemi, A. A., Oyewunmi, O. A., & Adejumobi, O. A. (2015). Chemopreventive effect of methanolic extract of Azadirachta indica on experimental Trypanosoma brucei induced oxidative stress in dogs. Pharmacognosy Research, 7(3), 249-258. https://doi.org/10.4103/0974-8490.157972

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    © 2015 Author(s)

    This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. CC BY-NC-SA 4.0