Pharmacognosy Research logo
Submit
Pharmacognosy ResearchACADEMIC PUBLISHING
Communication

In vivo anti-inflammatory and antiarthritic activities of aqueous extracts from Thymelaea hirsuta

1, 1★★ Corresponding author

  1. 1Department of Biology, Faculty of Sciences Ain Chock, Laboratory of Physiology and Molecular Genetics, Immunology Unit, University Hassan II, B.P. 5366, Mâarif, Casablanca, Morocco

CORRESPONDENCE

Mounia Oudghiri

Department of Biology, Faculty of Sciences Ain Chock, Laboratory of Physiology and Molecular Genetics, Immunology Unit, University Hassan II, B.P. 5366, Mâarif, Casablanca, Morocco

m.oudghiri@fsac.ac.ma

Volume 7, Issue 2 · pp. 213-216 · 2015 · DOI: 10.4103/0974-8490.150510

ABSTRACT

The aerial parts of Thymelaea hirsuta (TH) are used as a decoction in the treatment of different pathologies in folk medicine in Morocco. The aqueous extracts were evaluated for its anti-inflammatory activity and in inhibition of adjuvant induction arthritis in male Wistar rats. The anti-inflammatory activity was carried out using carrageenan-induced rat paw edema model, and the antiarthritic activity was carried out using complete Freund’s adjuvant-induced arthritis model. The plant extract (500 mg/kg body weight) exhibited significant activity in acute inflammation produced 60% of inhibition after 4 h as compared with that of the standard anti-inflammatory drug, the diclofenac (100 mg/kg) which showed 40% of inhibition. In arthritis model, the extract produced 85% inhibition after 18 days when compared with the diclofenac (10 mg/kg; 72%). These results indicate that the aqueous extract of TH had an anti-inflammatory activity and inhibited the induction of adjuvant arthritis in male Wistar rats.

KEYWORDS

Open in new tab

REFERENCES

As published

Showing references and in-text citations exactly as published.

    Cite this article

    SELECT FORMAT

    Azza, Z., & Oudghiri, M. (2015). In vivo anti-inflammatory and antiarthritic activities of aqueous extracts from Thymelaea hirsuta. Pharmacognosy Research, 7(2), 213-216. https://doi.org/10.4103/0974-8490.150510

    Copyright and licence

    © 2015 Author(s)

    This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. CC BY-NC-SA 4.0