Pharmacognosy Research logo
Submit
Pharmacognosy ResearchACADEMIC PUBLISHING
Communication

Anti-allergic activity of the Morinda citrifolia extract and its constituents

1, 2, 1, 1, 2, 2, 1★★ Corresponding author

  1. 1Faculty of Pharmacy, Kinki University 3-4-1 Kowakae, Higashiosaka, Osaka 577-8502
  2. 2Research and Development, Morinda Worldwide, Inc. 3-2-2 Nishishinjuku, Shinjuku-ku, Tokyo 160-0023, Japan

CORRESPONDENCE

Hideaki Matsuda

Faculty of Pharmacy, Kinki University, 3-4-1 Kowakae, Higashiosaka, Osaka 577-8502

matsuda@phar.kindai.ac.jp

Volume 6, Issue 3 · pp. 260-266 · 2014 · DOI: 10.4103/0974-8490.132608

ABSTRACT

Morinda citrifolia (Rubiaceae), commonly known as noni is distributed throughout tropical and sub-tropical regions of the world. Anti-allergic effects of noni have not been reported despite the clinical usage as an anti-allergic agent. To investigate the anti-allergic effects of the 50% ethanolic extract of M. citrifolia fruits and leaves (MCF-ext and MCL-ext), dinitrofluorobenzene (DNFB)-induced triphasic cutaneous reaction and picryl chloride-induced contact dermatitis (PC-CD) tests were performed. In DNFB-induced triphasic cutaneous reaction, oral administration of MCF-ext and MCL-ext exhibited dose-dependent inhibition of cutaneous reaction at 1 h (immediate phase response) after the DNFB challenge. MCF-ext also inhibited ear swelling at 24 h (late phase response) and 8 days (very late phase response) after the DNFB challenge. The effect of MCL-ext on the immediate phase response was attributed to the anti-degranulation from RBL-2H3 cells, while MCF-ext had no significant effect on degranulation. The active components of anti-degranulation activity in MCL-ext were determined to be ursolic acid, rutin and kaempferol-3-O-a-L-rhamnopyranosyl-(1®6)-b-D-glucopyranoside. In the PC-CD test, both MCF-ext and MCL-ext showed an anti-swelling effect but the potency of MCF-ext was stronger than MCL-ext. These data suggest that noni fruits and leaves can be a daily consumable material for the prevention of allergic symptoms.

KEYWORDS

Open in new tab

REFERENCES

As published

Showing references and in-text citations exactly as published.

    Cite this article

    SELECT FORMAT

    Murata, K., Abe, Y., Shinohara, K., Futamura-Masuda, M., Uwaya, A., Isami, F., & Matsuda, H. (2014). Anti-allergic activity of the Morinda citrifolia extract and its constituents. Pharmacognosy Research, 6(3), 260-266. https://doi.org/10.4103/0974-8490.132608

    Copyright and licence

    © 2014 Author(s)

    This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. CC BY-NC-SA 4.0