Pharmacognosy Research logo
Submit
Pharmacognosy ResearchACADEMIC PUBLISHING
Article

Margaritaria discoidea (Euphorbiaceae) stem bark extract attenuates allergy and Freund’s adjuvant-induced arthritis in rodents

1★, 1, 1, 1★ Corresponding author

  1. 1Department of Pharmacology, Faculty of Pharmacy and Pharm. Sciences, College of Health Sciences, KNUST, Kumasi, Ghana

CORRESPONDENCE

David D. Obiri

Department of Pharmacology, Faculty of Pharmacy and Pharm. Sciences, College of Health Sciences, KNUST, Kumasi, Ghana

ddobiri.pharm@knust.edu.gh

Volume 6, Issue 2 · pp. 163-171 · 2014 · DOI: 10.4103/0974-8490.129039

ABSTRACT

Various parts of Margaritaria discoidea find use in traditional medicine in the treatment of pain and oedema. This study evaluated the anti-allergic, anti-inflammatory and anti-arthritic effects of a 70% (v/v) aqueous ethanol extract of the stem bark of Margaritaria discoidea, MDE in rodents. Systemic anaphylaxis was induced by the injection of compound 48/80 into mice and their survival rate was monitored to evaluate the anti-allergic action of the extract. The effect of MDE assessed on the maximal and total oedema responses in the mouse carrageenan–induced paw oedema was used to evaluate the anti-inflammatory action of the extract while the Freund’s adjuvant-induced arthritis model was employed to study the anti-arthritic effects of MDE. MDE dose-dependently increased the time for compound 48/80-induced mortality in mice. MDE suppressed the mean maximal swelling and the total paw swellings induced over 6 h in the carrageenan-induced paw oedema when administered either prophylactically or therapeutically. MDE caused a reduction in serum levels of TNFa and IL-6 and significantly suppressed Freund’s adjuvant-induced arthritis. Margaritaria discoidea suppresses allergy and exhibits anti-inflammatory activity in mice. In addition it attenuates Freund’s adjuvant-induced arthritis through a reduction in serum levels of TNFa and IL-6 in rats.

KEYWORDS

Open in new tab

REFERENCES

As published

Showing references and in-text citations exactly as published.

    Cite this article

    SELECT FORMAT

    Obiri, D. D., Osafo, N., Oppong-Sarfo, J., & Prah, J. K. (2014). Margaritaria discoidea (Euphorbiaceae) stem bark extract attenuates allergy and Freund’s adjuvant-induced arthritis in rodents. Pharmacognosy Research, 6(2), 163-171. https://doi.org/10.4103/0974-8490.129039

    Copyright and licence

    © 2014 Author(s)

    This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. CC BY-NC-SA 4.0