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Antioxidant and toxicological evaluation of Cassia sophera in streptozotocin-induced diabetic Wistar rats

1, 1, 2★★ Corresponding author

  1. 1Departments of Biomedical Sciences, Bundelkhand University
  2. 2Zoology, Institute of Basic Sciences, Bundelkhand University, Jhansi, Uttar Pradesh, India

CORRESPONDENCE

Poonam Sharma

Zoology, Institute of Basic Sciences, Bundelkhand University, Jhansi, Uttar Pradesh, India

pnm245@yahoo.com

Volume 5, Issue 4 · pp. 225-232 · 2013 · DOI: 10.4103/0974-8490.118767

ABSTRACT

Multiple-organ failure is the main cause of death in diabetes mellitus (DM). Hyperglycemia-induced oxidative stress is responsible for major diabetic complications, including multiple-organ failure. Medicinal plants possessing antioxidant activity may reduce oxidative stress and improve the functions of various organs affected by hyperglycemia. This study was designed to evaluate the antioxidant effect of Aqueous Extract of Cassia sophera (AECS) in streptozotocin (STZ)-induced diabetic Wistar rats. AECS (200 mg/kg body weight (bw)) and the standard antidiabetic drug glibenclamide (10 mg/kgbw) were administered orally by gavaging for 28 days. Oral administration of AECS inhibited STZ-induced increase in lipid peroxidation (LPO), aspartate transaminase (AST), alanine transaminase (ALT), alkaline phosphatase (ALP), bilirubin, creatinine and urea in liver of diabetic rats. Significant increase in activity of superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx), and a reduced level of glutathione (GSH), were observed in the liver, kidney, pancreas and testis on AECS treatment. The results demonstrate that AECS is not only useful in controlling blood glucose, but also has antioxidant potential to protect the liver, kidney, pancreas and testis against damage caused by hyperglycemia-induced oxidative stress.

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    Singh, R., Bhardwaj, P., & Sharma, P. (2013). Antioxidant and toxicological evaluation of Cassia sophera in streptozotocin-induced diabetic Wistar rats. Pharmacognosy Research, 5(4), 225-232. https://doi.org/10.4103/0974-8490.118767

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    © 2013 Author(s)

    This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. CC BY-NC-SA 4.0