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The effects of unripe grape extract on systemic blood pressure, nitric oxide production, and response to angiotensin II administration

1★, 2, 3, 3, 3, 3★ Corresponding author

  1. 1Water and Electrolytes Research Center, 2Department of Physiology, 3Kidney Diseases Research Center
  2. 2Department of Pharmacognosy, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3Water and Electrolytes Research Center

CORRESPONDENCE

Mehdi Nematbakhsh

Water and Electrolytes Research Center

nematbakhsh@med.mui.ac.ir

Volume 5, Issue 2 · pp. 60-64 · 2013 · DOI: 10.4103/0974-8490.110511

ABSTRACT

Hypertension is the most common disease in the world. In Iranian folk medicine, unripe grape juice has been used as antihypertention remedy, but no data is documented for this popular belief. This study was designed to determine the effect of unripe grape extract (UGE) on blood pressure and the response to angiotensin II in rat. Unripe grape was collected, air dried, and extracted and concentrated. Four groups of Wistar rats received single doses of 125, 250, and 500 mg/kg of UGE or saline, respectively. The direct blood pressure and the serum nitrite level were measured one hour post UGE administration. The animals also were subjected to the infusion of various angiotensin II concentrations (100, 300, and 1000 mg/kg/min), and blood pressure was determined. Mean arterial, systolic, and diastolic pressures (MAP, SP, and DP) in all UGE treated groups were less than the control group, but only at the dose of 125 mg/kg (Group 1) they were significantly different (P < 0.05). The level of nitrite in groups 1-3 were significantly greater than the control group (P < 0.05). No significant differences were detected for the MAP, SP, and DP to different concentrations of angiotensin II among these groups. UGE potentially attenuate MAP, SP, and DP via vasodilatation induced by nitric oxide production.

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    Nematbakhsh, M., Zolfaghari, B., Eshraghi, F., Safari, T., Pezeshki, Z., & Sorooshzadeh, S. M. (2013). The effects of unripe grape extract on systemic blood pressure, nitric oxide production, and response to angiotensin II administration. Pharmacognosy Research, 5(2), 60-64. https://doi.org/10.4103/0974-8490.110511

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    © 2013 Author(s)

    This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. CC BY-NC-SA 4.0