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Dichlorvos and lindane induced oxidative stress in rat brain: Protective effects of ginger

1, 2★★ Corresponding author

  1. 1Departments of Zoology
  2. 2Biomedical Sciences, Bundelkhand University, Jhansi, Uttar Pradesh, India

CORRESPONDENCE

Rambir Singh

Biomedical Sciences, Bundelkhand University, Jhansi, Uttar Pradesh, India

sehrawat_r@yahoo.com

Volume 4, Issue 1 · pp. 27-32 · 2011 · DOI: 10.4103/0974-8490.91031

ABSTRACT

Dichlorvos and lindane pesticide causes toxicity in animals including humans. Ginger (Zingiber officinale) is widely used as a culinary medicine in the Ayurvedic system of medicine, possessing a number of pharmacological properties. This study was designed to assess ameliorating effects of ginger juice in dichlorvos and lindane induced neurotoxicity in wistar rats. Dichlorvos (8.8 mg/kg bw) and lindane (8.8 mg/kg bw) were orally administered alone as well as in combination to adult male and female wistar rats for 14 days followed by the post-treatment of ginger juice (100 mg/kg bw) for 14 days. Lipid peroxidation (LPO), reduced glutathione (GSH), and activities of antioxidant enzymes such as superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione S-transferase (GST), glutathione reductase (GR), quinine reductase (QR), and protein level were measured to evaluate the toxicity of these pesticides in brain. Dichlorvos and lindane administration alone and in combination increased LPO and decreased the GSH level, SOD, CAT, GPx, GST, GR, QR activity, and protein. Oxidative stress due to abnormal production of reactive oxygen species (ROS) is believed to be involved in the toxicities induced by these pesticides. Post-treatment of ginger juice decreased LPO and increased the level of GSH, SOD, CAT, GPx, GST, GR, QR activity and protein in the brain of rats. The results indicated that dichlorovos and lindane induced tissue damage was ameliorated by ginger juice.

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    Sharma, P., & Singh, R. (2011). Dichlorvos and lindane induced oxidative stress in rat brain: Protective effects of ginger. Pharmacognosy Research, 4(1), 27-32. https://doi.org/10.4103/0974-8490.91031

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    © 2011 Author(s)

    This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. CC BY-NC-SA 4.0