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Extract from peel of Citrus natsudaidai alleviates experimental chronic allergic dermatitis in mice

1, 1★, 1, 1★ Corresponding author

  1. 1Department of Geriatric Pharmacology and Therapeutics, Graduate School of Pharmaceutical Sciences, Chiba University

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Katsunori Yamaura

Department of Geriatric Pharmacology and Therapeutics, Graduate School of Pharmaceutical Sciences, Chiba University

yamaura@p.chiba-u.ac.jp

Volume 3, Issue 3 · pp. 155-159 · 2011 · DOI: 10.4103/0974-8490.84999

ABSTRACT

Citrus natsudaidai (natsumikan) is a typical citrus fruit containing several antioxidative nutrients which are found in higher concentration in the peel than in the pulp of the fruit. In this study, we examined whether extract from immature natsumikan peel prevents development of chronic allergic dermatitis in mice. Chronic allergic dermatitis was induced by repeated application of 2, 4, 6-trinitro-1-chlorobenzene in BALB/c mice and natsumikan was administrated orally for 30 days. Ear swelling and dermatitis score were measured after each challenge. The level of derivative-reactive oxygen metabolites (d-ROM) in serum was measured on day 30. Treatment of natsumikan significantly attenuated the increase in ear swelling and improved dermatitis scores. In addition, increases in serum d-ROM were attenuated by a treatment of natsumikan. Although the routine treatment with dexamethasone resulted in a clear and significant reduction in body weight, natsumikan treatment did not have such effects. Immature natsumikan peel is beneficial for the treatment of chronic allergic dermatitis.

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    Nakayama, N., Yamaura, K., Shimada, M., & Ueno, K. (2011). Extract from peel of Citrus natsudaidai alleviates experimental chronic allergic dermatitis in mice. Pharmacognosy Research, 3(3), 155-159. https://doi.org/10.4103/0974-8490.84999

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    © 2011 Author(s)

    This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. CC BY-NC-SA 4.0