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Immunomodulatory and erythropoietic effects of aqueous extract of the fruits of Solanum torvum Swartz (Solanaceae)

1★, 1, 1★ Corresponding author

  1. 1Department of Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences, College of Health Sciences, Kumasi, Ghana

CORRESPONDENCE

George A. Koffuor

Department of Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences, College of Health Sciences, Kumasi, Ghana

gkoffuor@yahoo.com

Volume 3, Issue 2 · pp. 130-134 · 2011 · DOI: 10.4103/0974-8490.81961

ABSTRACT

The effect of Solanum torvum (Fam: Solanaceae) on delayed type hypersensitivity (DTH) response, hemagglutinating antibody (HA) titer, white blood cells (WBC), red blood cells (RBC) and hemoglobin concentration was investigated in Sprague-Dawley rats to establish immunomodulatory and erythropoietic activity. Sheep red blood cells (SRBC)-immunized and challenged rats were treated with Solanum torvum extract, levamisole and dexamethasone. Phenylhydrazine (PHZ)-induced anemia in rats was treated with the extract. The aqueous Solanum torvum extract and levamisole significantly enhanced DTH response, increased HA titer and WBC count, while dexamethasone significantly decreased DTH response, did not increase HA titer, and did not enhance WBC profile. The extract and Feroglobin, the reference heamatinic, were able to reverse PHZ-induced anemia, and increase the RBCs and Hb concentration above baseline values within 24 days. Solanum torvum extract showed a concentration- dependent immunostimulant and erythropoietic activity.

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    Koffuor, G. A., Amoateng, P., & Andey, T. A. (2011). Immunomodulatory and erythropoietic effects of aqueous extract of the fruits of Solanum torvum Swartz (Solanaceae). Pharmacognosy Research, 3(2), 130-134. https://doi.org/10.4103/0974-8490.81961

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    © 2011 Author(s)

    This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. CC BY-NC-SA 4.0