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In vitro antiproliferative activity of Annona reticulata roots on human cancer cell lines

1★, 2, 3, 1, 1, 4★ Corresponding author

  1. 1Department of Pharmacognosy, H.K.E. Society’s College of Pharmacy, Gulbarga, Karnataka
  2. 2Department of Pharmaceutical Chemistry, B.L.D.E.A.’s College of Pharmacy, Bijapur, Karnataka
  3. 3Department of Pharmaceutical Chemistry, Mallareddy College of Pharmaceutical Sciences, Hyderabad
  4. 4Department of Biotechnology, Acharya Nagarjuna University, Guntur, AP, India

CORRESPONDENCE

H. M. Suresh

Department of Pharmacognosy, H.K.E. Society’s College of Pharmacy, Gulbarga, Karnataka

srsh_hm@rediffmail.com

Volume 3, Issue 1 · pp. 9-12 · 2011 · DOI: 10.4103/0974-8490.79109

ABSTRACT

The phytochemical and pharmacological activities of Annona reticulata components suggest a wide range of clinical application in lieu of cancer chemotherapy. Ethanol and aqueous extracts of roots of Annona reticulata Linn were studied for their in vitro antiproliferative activity on A-549 (human lung carcinoma), K-562 (human chronic myelogenous leukemia bone marrow), HeLa (human cervix) and MDA-MB (human adenocarcinoma mammary gland) cancer cell lines by MTT [3-(4,5-dimethyl thiazol-2-yl)-2,5-diphenyl tetrazolium bromide] colorimetric assay. The ethanol extract exhibited a prominent inhibitory effect against A-549, K-562, HeLa and MDA-MB human cancer cell lines at a concentration range between 10 and 40 μg/ml, whereas the aqueous extract showed a lower activity at the same concentration. Simultaneously, the effect of the ethanol extract toward the inhibition of Vero cell line proliferation was lower in comparison with the cancer cell lines. The significant antiproliferative activity of the ethanol extract of Annona reticulata roots against A-549, K-562, HeLa and MDA-MB human cancer cell lines may be attributed toward the collective presence of acetogenins, alkaloids and lower inhibitory effect on Vero cell line, which suggests Annona reticulata be used as a chemopreventive agent in cancer therapy.

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    Suresh, H. M., Shivakumar, B., Hemalatha, K., Heroor, S. S., Hugar, D. S., & Rao, K. R. S. S. (2011). In vitro antiproliferative activity of Annona reticulata roots on human cancer cell lines. Pharmacognosy Research, 3(1), 9-12. https://doi.org/10.4103/0974-8490.79109

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    © 2011 Author(s)

    This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. CC BY-NC-SA 4.0