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Solanum trilobatum in the management of atopy: Through inhibition of mast cell degranulation and moderation of release of interleukins

1★, 2, 3, 4, 5, 6, 3★ Corresponding author

  1. 1Faculty of Medicine, Microbiology Unit, AIMST University, Kedah, Malaysia.
  2. 2Department of Advanced Zoology and Biotechnology, Sri Paramakalyani College, Alwarkurichi.
  3. 3Faculty of Medicine, Microbiology Unit.
  4. 4Sri Paramakalyani Center for Environmental Sciences, M. S. University, Tirunelveli.
  5. 5Anatomy Unit, AIMST University, Kedah, Malaysia.
  6. 6R and D Center, Cholayil Private Limited, Chennai, India.

CORRESPONDENCE

M. S. Ranjith

Faculty of Medicine, Microbiology Unit, AIMST University, Kedah, Malaysia.

msranjith@yahoo.com

Received: 05-10-2009; Accepted: 13-03-2010.

Volume 2, Issue 1 · pp. 10-14 · 2010 · DOI: 10.4103/0974-8490.60581

ABSTRACT

Solanum trilobatum is a widely used plant in the Indian indigenous systems of medicine. It is mainly used in the treatment of respiratory diseases like bronchial asthma. In our present study, we report that the aqueous and alcoholic extracts of S. trilobatum exhibited inhibition of mast cell degranulation. Further, aqueous and alcoholic extracts of S. trilobatum significantly decreased the release of IL1a and increased the release of IL8 from the cultured keratinocytes. Oral administration of the aqueous and alcoholic extracts of S. trilobatum stabilized mast cells in experimental rats.

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    Ranjith, M. S., Ranjitsingh, A. J. A., Shankar, S. G., Vijayalaksmi, G. S., Deepa, K., Babu, K., & Sidhu, H. S. (2010). Solanum trilobatum in the management of atopy: Through inhibition of mast cell degranulation and moderation of release of interleukins. Pharmacognosy Research, 2(1), 10-14. https://doi.org/10.4103/0974-8490.60581

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    © 2010 Author(s)

    This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. CC BY-NC-SA 4.0