Article · Volume 17, Issue 3 · pp. 867-872

Fumaria parviflora Lam. Aqueous Extract Versus Simethicone in the Treatment of Infantile Colic: A Prospective Randomized Clinical Trial

Vahid Ramezani¹, Mahmood Noori Shadkam², Mobina Ghiasirad³, Sayedeh Ebrahimi³, Ali Mohammad Ranjbar³

¹Department of Pharmaceutics, Faculty of Pharmacy, Traditional Pharmacy and Pharmaceutical Sciences Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, IRAN.
²Department of Pediatrics and Mother and Newborn Health Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, IRAN.
³Department of Pharmacognosy, Faculty of Pharmacy, Shahid Sadoughi University of Medical Sciences, Yazd, IRAN.

Abstract

Infantile colic observes 10 to 40% of infants during first few months of life. The purpose of the present study was to evaluate the effectiveness of Fumaria parviflora Lam. (will fumitory) aqueous extract on infantile colic. A total of 52 breastfed infants suffering from infantile colic were randomly assigned to two groups. Will fumitory group and simethicone group received will fumitory extract and simethicone for 10 days, respectively. During the period of study, changing in infants’ colic symptoms including duration of crying, stooling frequency and consistency as well as probable side effects were inquired every day from the parents. The reduction in daily crying duration (0.05). No adverse effects related to will fumitory and simethicone group were observed. Will fumitory make a considerable improvement in colic related crying in comparison with simethicone. It was also well tolerable by infants suggesting as a new therapeutic approach in infantile colic.

Keywords: Fumaria parviflora Lam.; Infantile Colic; Simethicone; Will fumitory

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