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Solvent Polarity from Different Plant Extracts Deticate the Potential Activity against Infection by Methicillin-Resistant Staphylococcus aureus in Saudi Arabia

1, 2, 2, 3, 3, 2, 2, 4, 5

  1. 1Department of Biochemistry, Faculty of Science, King Abdulaziz University, Jeddah, SAUDI ARABIA., 2Experimental Biochemistry Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah, SAUDI ARABIA., 3Production of Bio-Products for Industrial Application Research Group, King Abdulaziz University, Jeddah, SAUDI ARABIA.
  2. 2Department of Biochemistry, Faculty of Science, King Abdulaziz University, Jeddah, SAUDI ARABIA.
  3. 3Experimental Biochemistry Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah, SAUDI ARABIA., 3Production of Bio-Products for Industrial Application Research Group, King Abdulaziz University, Jeddah, SAUDI ARABIA.
  4. 4Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, King Abdulaziz University, Jeddah, SAUDI ARABIA., 5Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Al-Azhar University, Cairo, EGYPT.
  5. 5Biochemistry Department, Faculty Of Science, Ain Shams University, Cairo, EGYPT.

CORRESPONDENCE

Taha A. Kumosani

Department of Biochemistry, Faculty of Science, King Abdulaziz University, Jeddah, SAUDI ARABIA.

tkumosani@gmail.com

Received: 19-10-2023; Accepted: 18-12-2023.

Volume 16, Issue 2 · pp. 300-304 · 2024 · DOI: 10.5530/pres.16.2.38

ABSTRACT

Background: Skin infection by Methicillin-Resistant Staphylococcus aureus (MRSA) is a common disease in Saudi Arabia. This bacterium is resistance to Methicillin and other antibiotics. Skin and soft tissue are the greatest common infected areas by these strains include abscesses, wound infections and other diseases.Materials and Methods: This study evaluated the in vitro antibacterial action of different plants extracts using different solvents from Saudi Arabia against MRSA. Different Plants were extracted by different solvents: methanol, chloroform and n-hexane. Agar well diffusion method was used to determine antibacterial efficacy with 100 μL (5 mg /0.5 mL) of plant extracts.Results: Minimum inhibitory concentration was determined on plant extracts that showed high effectiveness against MRSA.Conclusion: The obtained from Gas chromatography/mass spectrum analysis of the most active four plants, revealed the active volatile oils and flavonoids contents of Artemisia monosperma, Mentha longifolia, Vernonia schimperi and Rumex nervosu have antibacterial activity against MRSA. These plants demonstrate promising anti-MRSA potential.

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    Kumosani, T. A., Alshehri, S. H., Eissa, F. A., Barbour, E. K., Yaghmoor, S. S., Albogami, T. J., Sunble, S. N., Abdelnapy, T. A., & Moselhy, S. S. (2024). Solvent Polarity from Different Plant Extracts Deticate the Potential Activity against Infection by Methicillin-Resistant Staphylococcus aureus in Saudi Arabia. Pharmacognosy Research, 16(2), 300-304. https://doi.org/10.5530/pres.16.2.38

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    © 2024 Author(s)

    This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. CC BY-NC-SA 4.0