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PR · Lens · Anti-arthritic Potential of Aqueous and Ethanolic Extracts of Euphorbia helioscopia on Adjuvant-induced Arthritis in Rats

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Article · Volume 14, Issue 3 · pp. 304-309

Anti-arthritic Potential of Aqueous and Ethanolic Extracts of Euphorbia helioscopia on Adjuvant-induced Arthritis in Rats

Iram Jan1, Ashish Dogra2, Syed Assim Haq2, Sumit Dhiman3, Gurdarshan Singh2,3, Mithilesh Kumar4

  1. 1School of Life Sciences, Jaipur National University, Jaipur, Rajasthan, INDIA., 3PK-PD Toxicology and Formulation Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu, Jammu and Kashmir, INDIA.
  2. 2Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, INDIA., 3PK-PD Toxicology and Formulation Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu, Jammu and Kashmir, INDIA.
  3. 3PK-PD Toxicology and Formulation Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu, Jammu and Kashmir, INDIA.
  4. 4School of Life Sciences, Jaipur National University, Jaipur, Rajasthan, INDIA.

Abstract

Background: Euphorbia helioscopia is of the family Euphorbiaceae, owning various pharmacological properties like anti-inflammatory activity. Rheumatoid Arthritis (RA) is a chronic-autoimmune systemic disease that can be characterized by cartilage degradation, synovial hyperplasia, inflammation, and joint damage.Objectives: To assess the anti-arthritic activity of aqueous and ethanolic extracts of Euphorbia helioscopia.Materials and Methods: Adjuvant-induced arthritis (AIA) method was followed for the evaluation. Complete Freund’s adjuvant (CFA) was used to induce arthritis in female Wistar rats. Aqueous and ethanolic extracts (300, 150, and 75 mg/kg/day) of aerial parts of Euphorbia helioscopia were given orally to Wistar rats.Results: Both the extracts showed significant anti-arthritic activity in a dose-dependent manner. However, ethanolic extract (300mg/kg) of Euphorbia helioscopia showed potential anti-arthritic activity among the tested extracts.Conclusion: From the study, it can be concluded that Euphorbia helioscopia possesses marked anti-arthritic activity.

Keywords: Adjuvant induced arthritis; Antiinflammatory; Aqueous and ethanolic plant extracts; Euphorbia helioscopia; Rheumatoid Arthritis

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