Anti-leukemia Activity of Methanolic Extracts of Lantana camara
1, 1, 1, 2
- 1Department of Biotechnology, Faculty of Applied Sciences, AIMST University, 08100 Semeling- Bedong, Kedah, Malaysia.
- 2Centre for Drug Research, University Science of Malaysia, 11800 Minden, Pulau Pinang. Malaysia.
CORRESPONDENCE
Badakhshan Mahdi Pour
Department of Biotechnology, Faculty of Applied Sciences, AIMST University, 08100 Semeling- Bedong, Kedah, Malaysia.
Received: 22-06-2009; Accepted: 22-08-2009.
Volume 1, Issue 5 · pp. 274-279 · 2009 · DOI:
ABSTRACT
Anticancer effect of Lantana camara’s root and leaf extracts against Jurkat leukemia cell line was investigated by MTT assay. These extracts had statistically similar antineoplastic property (root IC50, 328.36 ± 53.08 μg/ml; leaf, 394.41 ± 99.73 μg/ml; p > 0.1, n = 3), averagely 1/10 times as activity as carboplatin (IC50 34.83 ± 3.60 μg/ml; p < 0.05, n = 3). Decreasing cytotoxicity at higher concentrations implied the existence of cytoprotective compounds. Morphological examinations indicated apoptosis induction as the mechanism of activity on Jurkat cells. In conclusion, L. camara’s root and leaf extracts might be subjects for further fractionation and identification to find new anticancer agents.
KEYWORDS
REFERENCES
As publishedShowing references and in-text citations exactly as published.
Cite this article
SELECT FORMAT
Pour, B. M., Sasidharan, S., Jegathambigai, R. N., & Surash, R. (2009). Anti-leukemia Activity of Methanolic Extracts of Lantana camara. Pharmacognosy Research, 1(5), 274-279.
Copyright and licence
© 2009 Author(s)
This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. CC BY-NC-SA 4.0