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  Indian J Med Microbiol
 

Figure 4: Overview of lactoferrin mediated inhibition of interleukin-1β.induced signaling events to cyclooxygenase-2 in human osteoarthritis chondrocytes. Interleukin-1β through interleukin-1 receptor activates interleukin-1β-induced signaling to cyclooxygenase-2 or prostaglandin E2 via activation of nuclear transcription factor-kappa B. Nuclear factor-kappa B complex was demonstrated by nuclear nuclear factor-kappa Bp65. All possible offered targets of lactoferrin induced inhibition to cyclooxygenase are shown. IL-1β: interleukin-1 beta; IL-1R: receptor for IL.1; L: lactoferrin; NF-κB: Nuclear factor-kappa B; p-NF-κB: phosphorylated NF-κB; COX-2: cyclooxygenase-2; PGE2: prostaglandin E2

Figure 4: Overview of lactoferrin mediated inhibition of interleukin-1β.induced signaling events to cyclooxygenase-2 in human osteoarthritis chondrocytes. Interleukin-1β through interleukin-1 receptor activates interleukin-1β-induced signaling to cyclooxygenase-2 or prostaglandin E2 via activation of nuclear transcription factor-kappa B. Nuclear factor-kappa B complex was demonstrated by nuclear nuclear factor-kappa Bp65. All possible offered targets of lactoferrin induced inhibition to cyclooxygenase are shown. IL-1β: interleukin-1 beta; IL-1R: receptor for IL.1; L: lactoferrin; NF-κB: Nuclear factor-kappa B; p-NF-κB: phosphorylated NF-κB; COX-2: cyclooxygenase-2; PGE<sup>2</sup>: prostaglandin E2