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  Indian J Med Microbiol
 

Figure 3: Anti-inflammatory effect of UP1304 as measured by ankle diameter in adjuvant-induced arthritis. Arthritis was induced by sensitizing rats with an injection of complete Freund's adjuvant containing 5 mg/mL (W/V) suspension of heat killed mycobacterium tuberculosis in liquid paraffin into subplantar region of right hind paw of sedated rats (N = 10). Data are expressed as mean ± standard error. All treatment groups showed statistical significance at P ≤ 0.001 versus vehicle at day 3, 5, 9, and 13. †P ≤ 0.001 versus vehicle for the 200 mg/kg and 100 mg/kg UP1304; *P ≤ 0.01 versus vehicle for ibuprofen and 50 mg/kg UP1304

Figure 3: Anti-inflammatory effect of UP1304 as measured by ankle diameter in adjuvant-induced arthritis. Arthritis was induced by sensitizing rats with an injection of complete Freund's adjuvant containing 5 mg/mL (W/V) suspension of heat killed mycobacterium tuberculosis in liquid paraffin into subplantar region of right hind paw of sedated rats (<i>N</i> = 10). Data are expressed as mean ± standard error. All treatment groups showed statistical significance at <i>P</i> ≤ 0.001 versus vehicle at day 3, 5, 9, and 13. †<i>P</i> ≤ 0.001 versus vehicle for the 200 mg/kg and 100 mg/kg UP1304; *<i>P</i> ≤ 0.01 versus vehicle for ibuprofen and 50 mg/kg UP1304