Pharmacognosy Research

ORIGINAL ARTICLE
Year
: 2021  |  Volume : 13  |  Issue : 2  |  Page : 82--88

Leaf extracts of Glyphaea brevis attenuate high blood glucose and lipids in diabetic rats induced with streptozotocin


William Dakam1, Christine Fernande Nyangono Biyegue2, Simone Véronique Fannang3, Julius Enyong Oben4 
1 Department of Biological Sciences, Faculty of Medicine and Pharmaceutical Sciences, University of Douala, Cameroon
2 Department of Home Economics, Higher Teachers Training College for Technical Education, University of Douala, Cameroon
3 Department of Pharmaceutical Sciences, Faculty of Medicine and Pharmaceutical Sciences, University of Douala, Cameroon
4 Department of Biochemistry, Faculty of Science, University of Yaoundé 1, Cameroon

Correspondence Address:
Dr. William Dakam
Faculty of Medicine and Pharmaceutical Sciences, University of Douala, P.O. Box 3342, Douala
Cameroon

Background: Diabetes is a non-communicable disease causing impairment of carbohydrate and lipid metabolisms. Previous ethnobotanical surveys showed that leaves of Glyphaea brevis (G. brevis) are used conventionally in the treatment of diabetes with limited scientific evidence. Objective: We aimed to determine the effects of aqueous (AE) and hydroethanolic extracts (HEE) of G. brevis leaves in attenuating diabetes-linked hyperglycemia and hyperlipidemia in an animal model. Materials and Methods: Thirty streptozotocin-induced diabetic male rats were divided into six groups receiving the following daily treatments for 4 weeks orally: control (distilled water), reference (tolbutamide 80 mg/kg) and 4 tests (AE 250 mg/kg, AE 500 mg/kg, HEE 250 mg/kg, and HEE 500 mg/kg). The effects of each treatment on postprandial hyperglycemia were assessed using oral glucose tolerance and oral starch tolerance tests. Blood was collected to assess the effects of treatments on fasting plasma glucose, glycated hemoglobin (HbA1c), and lipid profile. Liver glycogen and gluconeogenic enzyme activity were also measured. Results: AE- and HEE-treated rats had 36%–64% lower fasting blood glucose levels, 34%–73% lower postprandial glycemia, and 15%–75% lower HbA1c than rats from control group (P < 0.01). AE and HEE treatments also brought about a significant increase in liver glycogen levels and lower gluconeogenic enzyme activity (P < 0.01). Extract-treated groups also had lower plasma total cholesterol and low-density lipoprotein-cholesterol concentrations (P < 0.01). Conclusion: These results suggest that treatment with leaf extracts of G. brevis is effective in attenuating hyperglycemia and hyperlipidemia in streptozotocin-induced diabetic rats. Future studies will determine the active compounds accountable for these beneficial effects.


How to cite this article:
Dakam W, Biyegue CF, Fannang SV, Oben JE. Leaf extracts of Glyphaea brevis attenuate high blood glucose and lipids in diabetic rats induced with streptozotocin.Phcog Res 2021;13:82-88


How to cite this URL:
Dakam W, Biyegue CF, Fannang SV, Oben JE. Leaf extracts of Glyphaea brevis attenuate high blood glucose and lipids in diabetic rats induced with streptozotocin. Phcog Res [serial online] 2021 [cited 2021 Jun 17 ];13:82-88
Available from: http://www.phcogres.com/article.asp?issn=0974-8490;year=2021;volume=13;issue=2;spage=82;epage=88;aulast=Dakam;type=0