ORIGINAL ARTICLE
Year : 2017 | Volume
: 9 | Issue : 1 | Page : 80--86
Antidiabetic effects of aqueous and dichloromethane/methanol stem bark extracts of Pterocarpus soyauxii Taub (Papilionaceae) on streptozotocin-induced diabetic rats
Marie Claire Tchamadeu, Paul Désiré Djomeni Dzeufiet, Nelly Blaes, Jean-Pierre Girolami, Pierre Kamtchouing, Théophile Dimo
Department of Animal Biology Organisms, Faculty of Science, University of Douala, 24157, Douala; Department of Animal Biology and Physiology, Faculty of Science, University of Yaounde 1, 812, Yaounde, Cameroon; INSERM, U1048, I2MC Institute of Metabolic and Cardiovascular diseases, University of Toulouse III, F31432, Toulouse, France
Correspondence Address:
Marie Claire Tchamadeu
Department of Animal Biology Organisms, Faculty of Science, University of Douala, P. O. Box: 24157, Douala
Aim of the Study: The aim is to evaluate the hypoglycemic and antidiabetic effects of aqueous and CH2Cl2/CH3OH stem bark extracts of Pterocarpus soyauxii Taub in normal and diabetic rats. Materials and Methods: Streptozotocin (STZ)-induced diabetic and normal adult Wistar rats were orally administered with aqueous and CH2Cl2/CH3OH plant extracts of P. soyauxii at various doses (38–300 mg/kg) in a single administration. In addition, STZ-induced diabetic rats received prolonged daily administration for 14 days. Glibenclamide (GB) (10 mg/kg) was used as reference treatment. In acute test, fasting blood glucose was followed for 5 h. In subacute test, body weight, food and water intakes, and blood glucose were followed weekly and serum biochemical parameters evaluated after 14 days treatment. Results: Acute administration of aqueous and CH2Cl2/CH3OH stem bark extracts moderately decreased fasting blood glucose compared to GB, significantly in normal rats (P < 0.05 to P < 0.01) but, as GB, not significantly in diabetic rats. Prolonged treatments in diabetic rats with aqueous and CH2Cl2/CH3OH extracts reduced blood glucose to an extent, respectively, superior or similar to GB. Moreover, P. soyauxii also significantly (P < 0.01) reduced weight loss, and diabetes increased serum triglycerides, total cholesterol, and transaminases (alanine aminotransferase/aspartate aminotransferase) elevations. Conclusion: P. soyauxii Taub stem bark extracts have possible value for antidiabetic oral medication.
How to cite this article:
Tchamadeu MC, Dzeufiet PD, Blaes N, Girolami JP, Kamtchouing P, Dimo T. Antidiabetic effects of aqueous and dichloromethane/methanol stem bark extracts of Pterocarpus soyauxii Taub (Papilionaceae) on streptozotocin-induced diabetic rats.Phcog Res 2017;9:80-86
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How to cite this URL:
Tchamadeu MC, Dzeufiet PD, Blaes N, Girolami JP, Kamtchouing P, Dimo T. Antidiabetic effects of aqueous and dichloromethane/methanol stem bark extracts of Pterocarpus soyauxii Taub (Papilionaceae) on streptozotocin-induced diabetic rats. Phcog Res [serial online] 2017 [cited 2021 Jan 25 ];9:80-86
Available from: http://www.phcogres.com/article.asp?issn=0974-8490;year=2017;volume=9;issue=1;spage=80;epage=86;aulast=Tchamadeu;type=0 |
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