Pharmacognosy Research

ORIGINAL ARTICLE
Year
: 2016  |  Volume : 8  |  Issue : 1  |  Page : 1--7

Effect of Beta vulgaris Linn. leaves extract on anxiety- and depressive-like behavior and oxidative stress in mice after acute restraint stress


Kunjbihari Sulakhiya1, Vikas Kumar Patel1, Rahul Saxena1, Jagrati Dashore1, Amit Kumar Srivastava2, Manoj Rathore3 
1 Department of Pharmacology, Ravishankar College of Pharmacy, Bhopal, Madhya Pradesh, India
2 Department of Pharmacology, Sapience Bio-analytical Research Laboratory, Bhopal, Madhya Pradesh, India
3 School of Pharmacy, DAVV University, Indore, Madhya Pradesh, India

Correspondence Address:
Dr. Kunjbihari Sulakhiya
Department of Pharmacology, Ravishankar College of Pharmacy, Bhanpur-Karond Road, Bhanpur Square, Bhopal, Madhya Pradesh - 462 010
India

Background: Stress plays a significant role in the pathogenesis of neuropsychiatric disorders such as anxiety and depression. Beta vulgaris is commonly known as DQbeet rootDQ possessing antioxidant, anticancer, hepatoprotective, nephroprotective, wound healing, and anti-inflammatory properties. Objective: To study the protective effect of Beta vulgaris Linn. ethanolic extract (BVEE) of leaves against acute restraint stress (ARS)-induced anxiety- and depressive-like behavior and oxidative stress in mice. Materials and Methods: Mice (n = 6) were pretreated with BVEE (100 and 200 mg/kg, p. o.) for 7 days and subjected to ARS for 6 h to induce behavioral and biochemical changes. Anxiety- and depressive-like behavior were measured by using different behavioral paradigms such as open field test (OFT), elevated plus maze (EPM), forced swim test (FST), and tail suspension test (TST) 40 min postARS. Brain homogenate was used to analyze oxidative stress parameters, that is, malondialdehyde (MDA) and reduced glutathione (GSH) level. Results: BVEE pretreatment significantly (P < 0.05) reversed the ARS-induced reduction in EPM parameters, that is, percentage entries and time spent in open arms and in OFT parameters, that is, line crossings, and rearings in mice. ARS-induced increase in the immobility time in FST and TST was attenuated significantly (P < 0.05) by BVEE pretreatment at both the dosage. An increase in MDA and depletion of GSH level postARS was prevented significantly (P < 0.05) with BVEE pretreatment at both the dosage (100 and 200 mg/kg). Conclusion: BVEE exhibits anxiolytic and antidepressant activity in stressed mice along with good antioxidant property suggesting its therapeutic potential in the treatment of stress-related psychiatric disorders.


How to cite this article:
Sulakhiya K, Patel VK, Saxena R, Dashore J, Srivastava AK, Rathore M. Effect of Beta vulgaris Linn. leaves extract on anxiety- and depressive-like behavior and oxidative stress in mice after acute restraint stress.Phcog Res 2016;8:1-7


How to cite this URL:
Sulakhiya K, Patel VK, Saxena R, Dashore J, Srivastava AK, Rathore M. Effect of Beta vulgaris Linn. leaves extract on anxiety- and depressive-like behavior and oxidative stress in mice after acute restraint stress. Phcog Res [serial online] 2016 [cited 2021 Jun 19 ];8:1-7
Available from: http://www.phcogres.com/article.asp?issn=0974-8490;year=2016;volume=8;issue=1;spage=1;epage=7;aulast=Sulakhiya;type=0