Pharmacognosy Research

ORIGINAL ARTICLE
Year
: 2015  |  Volume : 7  |  Issue : 5  |  Page : 34--38

Hematological effects of repeated graded doses of the methanol extract of Paullinia pinnata (Linn.) leaves in Wistar albino rats


Oluwatoyin A Adeyemo-Salami1, Emmanuel O Ewuola2 
1 Department of Biochemistry, College of Medicine, University of Ibadan, Ibadan, Oyo State, Nigeria
2 Animal Physiology Laboratory, Department of Animal Science, University of Ibadan, Ibadan, Oyo State, Nigeria

Correspondence Address:
Oluwatoyin A Adeyemo-Salami
Department of Biochemistry, College of Medicine, University of Ibadan, U.I.P.O. Box 9761, 200005, Ibadan, Oyo State
Nigeria

Background: Paullinia pinnata is a medicinal plant used for the treatment of various diseases, including anemia in West Africa. Aim: This study was carried out to investigate the effect of increasing doses of the methanolic leaves extract of P. pinnata on hematological parameters in rats. Materials and Methods: Thirty-six male Wistar albino rats were grouped into six groups of six animals each. Five doses; 50,100, 200, 400 and 800 mg/kg body weight of the P. pinnata extract were administered separately to five groups. The sixth group served as a control and received only the vehicle (70% physiological saline: 30% Tween 80 [v/v]). Administration was done orally daily for 28 days at 24 h interval. On day 29, the animals were made inactive, blood was then collected from the heart and various hematological parameters were evaluated. Statistical Analysis: Analysis of variance was employed. Results: The packed cell volume and red blood cell count increased significantly (P < 0.05) in the treatment groups except at 200 mg/kg dose. The hemoglobin concentration increased in all the treatment groups. The values for the neutrophils at 50, 100, 200 and 800 mg/kg doses were higher than that of the control. The white blood cell count increased significantly (P < 0.05) at 50 and 400 mg/kg doses compared to the control and exceeded the normal physiological range. Conclusion: The maximum tolerable dose is 200 mg/kg body weight of the methanolic leaves extract of P. pinnata and the extract has anti-anemic property with the ability to increase neutrophils count.


How to cite this article:
Adeyemo-Salami OA, Ewuola EO. Hematological effects of repeated graded doses of the methanol extract of Paullinia pinnata (Linn.) leaves in Wistar albino rats.Phcog Res 2015;7:34-38


How to cite this URL:
Adeyemo-Salami OA, Ewuola EO. Hematological effects of repeated graded doses of the methanol extract of Paullinia pinnata (Linn.) leaves in Wistar albino rats. Phcog Res [serial online] 2015 [cited 2021 Apr 21 ];7:34-38
Available from: http://www.phcogres.com/article.asp?issn=0974-8490;year=2015;volume=7;issue=5;spage=34;epage=38;aulast=Adeyemo-Salami;type=0