Pharmacognosy Research

ORIGINAL ARTICLE
Year
: 2015  |  Volume : 7  |  Issue : 2  |  Page : 184--187

Serum total antioxidant capacity in oral carcinoma patients


KS Rathan Shetty1, Arunava Kali2, KS Rachan Shetty3 
1 Department of Otorhinolaryngology, Mahatma Gandhi Medical College and Research Institute, Puducherry, India
2 Department of Microbiology, Mahatma Gandhi Medical College and Research Institute, Puducherry, India
3 Department of Medical Oncology, Kidwai Memorial Institute of Oncology, Bengaluru, Karnataka, India

Correspondence Address:
Arunava Kali
Department of Microbiology, Mahatma Gandhi Medical College and Research Institute, Puducherry 607 402
India

Context: Oxidative stress is a major determinant in carcinogenesis and serum total antioxidant capacity (TAC) indirectly reflects the level of oxidative stress. Although oral cancer is the third most frequent cancer in Indian population, there are no standard noninvasive marker for early detection and monitoring therapeutic response in oral cancer patients. Aims: This study was carried out to investigate implications of serum TAC in oral cancer by evaluating pre- and post-operative levels in oral cancer patients. Settings and Designs: It was a prospective single blinded study. Subjects and Methods: Serum TAC was measured using ferric-reducing antioxidant power assay. Pre- and post-operative values were estimated and compared in 30 oral cancer patients who underwent surgery. Statistical Analysis Used: Paired t-test was used to compare pre- and post-operative values. Results: Compared to the normal value, both pre- and post-operative serum TAC were significantly low in oral cancer patients. However, there was no statistically significant difference between pre- and postoperative levels. Conclusions: In this study, low mean serum TAC was detected in oral cancer patients. However, its diagnostic and prognostic significance in oral cancer needs further investigation.


How to cite this article:
Rathan Shetty K S, Kali A, Rachan Shetty K S. Serum total antioxidant capacity in oral carcinoma patients.Phcog Res 2015;7:184-187


How to cite this URL:
Rathan Shetty K S, Kali A, Rachan Shetty K S. Serum total antioxidant capacity in oral carcinoma patients. Phcog Res [serial online] 2015 [cited 2021 Apr 21 ];7:184-187
Available from: http://www.phcogres.com/article.asp?issn=0974-8490;year=2015;volume=7;issue=2;spage=184;epage=187;aulast=Rathan;type=0