Pharmacognosy Research

ORIGINAL ARTICLE
Year
: 2015  |  Volume : 7  |  Issue : 1  |  Page : 18--22

Evaluation of anti-inflammatory activity of methanolic extract of leaves of Bougainvillea spectabilis in experimental animal models


Gautam Mandal1, Chandan Chatterjee2, Mitali Chatterjee3 
1 Department of Pharmacology, IPGME and R and SSKM Hospital, Kolkata, West Bengal, India
2 Department of Pharmacology, ESIC PGIMSR Medical College and Model Hospital, Kolkata, West Bengal, India
3 Department of Pharmacology, IPGME&R and SSKM Hospital, Kolkata, West Bengal, India

Correspondence Address:
Chandan Chatterjee
358, NSC Bose Road, Kolkata, West Bengal - 700 047
India

Background: Bougainvillea spectabilis (BS) (family Nyctaginaceae) is said to possess hypoglycemic and anti-inflammatory activities in experimental animals. We had set forward to examine the potential anti-inflammatory activities of BS in experimental models of inflammation. Materials and Methods: Fresh dried leaves from the flowering plant of BS were collected from the local area during the flowering season and air dried (215.00 g). Methanol was extracted, and the solvent was removed on a rotary evaporator under reduced pressure. The extract was freeze-dried (lyophilized) and the yield was 8 g. This was used as an emulsion prepared in propylene glycol and orally administered (20 and 50 mg/kg). Acute anti-inflammatory activity of BS was evaluated using carrageenan and dextran whereas chronic anti-inflammatory (immunoregulatory) activity was evaluated by Freund«SQ»s adjuvant-induced arthritis model. Results: BS (20 mg/kg and 50 mg/kg) had shown significant anti-inflammatory effects 20.6% and 67.6%, respectively, on carrageenan-induced acute inflammatory models. In dextran-induced edema, the effect was 30% and 66%, respectively. The standard drug indomethacin (87.3% and 91.5%, respectively) showed better inhibitory response in both models. In arthritic model 50 mg/kg of BS showed significant chronic anti-inflammatory effect (38.46%) in comparison to the standard drug dexamethasone (84.6%). Conclusion: Our data indicate that the methanol extract of BS (50 mg/kg) leaves has significant anti-inflammatory and immunoregulatory activity. Further studies involving isolation of active principles will help to pinpoint the mechanisms contributing to the observed activities of BS.


How to cite this article:
Mandal G, Chatterjee C, Chatterjee M. Evaluation of anti-inflammatory activity of methanolic extract of leaves of Bougainvillea spectabilis in experimental animal models.Phcog Res 2015;7:18-22


How to cite this URL:
Mandal G, Chatterjee C, Chatterjee M. Evaluation of anti-inflammatory activity of methanolic extract of leaves of Bougainvillea spectabilis in experimental animal models. Phcog Res [serial online] 2015 [cited 2020 Nov 30 ];7:18-22
Available from: http://www.phcogres.com/article.asp?issn=0974-8490;year=2015;volume=7;issue=1;spage=18;epage=22;aulast=Mandal;type=0