Pharmacognosy Research

ORIGINAL ARTICLE
Year
: 2014  |  Volume : 6  |  Issue : 3  |  Page : 246--250

Effect of ethanolic extract of Acacia auriculiformis leaves on learning and memory in rats


Ajitha Sharma1, Manjunath Shetty2, Amrita Parida3, Shalini Adiga3, Shobha Kamath4, Sowjanya4 
1 Department of Pharmacology, Pondicherry Institute of Medical Sciences, Puducherry, India
2 Melaka Malaysian Medical College, Manipal, Karnataka, India
3 Kasturba Medical College, Manipal, Karnataka, India
4 Department of Biochemistry, Kasturba Medical College, Manipal, Karnataka, India

Correspondence Address:
Dr. Ajitha Sharma
Department of Pharmacology; Pondicherry Institute of Medical Sciences, Puducherry
India

Background: The effects and benefits of Acacia auriculiformis on health are not well established. This study was planned to evaluate the effect of ethanolic extract of Acacia auriculiformis leaves on learning and memory in rats. Materials and Methods: Learning and memory were evaluated using passive avoidance paradigm and rewarded alternation test (T-maze) after the oral administration of two doses (200mg/kg and 400mg/kg) of ethanolic extract of Acacia auriculiformis with rivastigmine as positive control. Forty eight rats were divided into 4 groups in each study model. Estimation of brain cholinesterase activity was done to substantiate the results of the above mentioned tests. Data was analyzed using one way Analysis of Variance (ANOVA) followed by Tukey«SQ»s post-hoc test using GraphPad InStat software, version 3.06. Results: The extract produced a dose-dependent improvement in the memory score namely the step through latency in passive avoidance model (P < 0.001) and the percentage of correct responses in rewarded alternation test (P < 0.05). Dose-dependent inhibition of brain cholinesterase activity (P < 0.001) was also noted. Conclusion: The acetylcholinesterase inhibiting property of Acacia auriculiformis contributes to its memory enhancing potential. Further large scale studies are required to elucidate its benefits on cognitive function. This may offer a promising new option for the treatment of dementia and other cognitive deficits.


How to cite this article:
Sharma A, Shetty M, Parida A, Adiga S, Kamath S, Sowjanya. Effect of ethanolic extract of Acacia auriculiformis leaves on learning and memory in rats.Phcog Res 2014;6:246-250


How to cite this URL:
Sharma A, Shetty M, Parida A, Adiga S, Kamath S, Sowjanya. Effect of ethanolic extract of Acacia auriculiformis leaves on learning and memory in rats. Phcog Res [serial online] 2014 [cited 2020 Nov 26 ];6:246-250
Available from: http://www.phcogres.com/article.asp?issn=0974-8490;year=2014;volume=6;issue=3;spage=246;epage=250;aulast=Sharma;type=0