Pharmacognosy Research

ORIGINAL ARTICLE
Year
: 2013  |  Volume : 5  |  Issue : 4  |  Page : 306--308

Mast cell stabilization potential of Sitopaladi churna: An ayurvedic formulation


Inder K Makhija, Chandrashekara S Shreedhara, H.N. Aswatha Ram 
 Department of Pharmacognosy, Manipal College of Pharmaceutical Sciences, Manipal University, Karnataka, India

Correspondence Address:
H.N. Aswatha Ram
Department of Pharmacognosy, Manipal College of Pharmaceutical Sciences, Manipal University, Karnataka
India

Background: Sitopaladi churna (SPC) is a popular polyherbal ayurvedic formulation used in the treatment of allergy and respiratory diseases. Objective: The present study was aimed to justify the classical use of antiallergic claim by performing the mast cell stabilizing activity of extracts of SPC. Materials and Methods: The protective effect of aqueous extract and methanolic extract - of SPC against compound 48/80-induced mast cell degranulation model was carried out. Results: Sitopaladi churna aqueous extract (SPCA) at the dose of 300 mg/kg and Sitopaladi churna methanolic extract (SPCM) at the doses of 150 and 300 mg/kg showed better protection of mast cell degranulation (65%-74%) and were comparable to the standard drug ketotifen (79%), when peritoneal mast cells were treated with compound 48/80. The protection against mast cell degranulation was significant (P < 0.0001). Conclusion: From the above results, it has been justified that SPC can be used to treat allergic disorders.


How to cite this article:
Makhija IK, Shreedhara CS, Ram HA. Mast cell stabilization potential of Sitopaladi churna: An ayurvedic formulation.Phcog Res 2013;5:306-308


How to cite this URL:
Makhija IK, Shreedhara CS, Ram HA. Mast cell stabilization potential of Sitopaladi churna: An ayurvedic formulation. Phcog Res [serial online] 2013 [cited 2021 Apr 21 ];5:306-308
Available from: http://www.phcogres.com/article.asp?issn=0974-8490;year=2013;volume=5;issue=4;spage=306;epage=308;aulast=Makhija;type=0