Pharmacognosy Research

ORIGINAL ARTICLE
Year
: 2013  |  Volume : 5  |  Issue : 4  |  Page : 286--290

Antinociceptive and anticonvulsant activities of hydroalcoholic extract of Jasminum grandiflorum (jasmine) leaves in experimental animals


Rajesh K Gupta, Pooja S Reddy 
 Department of Pharmacology, MGIMS, Sevagram, Maharashtra, India

Correspondence Address:
Pooja S Reddy
Department of Pharmacology, MGIMS, Sevagram, Maharashtra
India

Jasminum grandiflorum belongs to the family Oleaceae and is known to have anti-inflammatory, antimicrobial, antioxidant, and antiulcer activities. The present study was undertaken to study its analgesic and anticonvulsant effects in rats and mice. The antinociceptive activity of the hydroalcoholic extract of J. grandiflorum leaves (HEJGL) was studied using tail flick and acetic acid - induced writhing method. Similarly, its anticonvulsant activity was observed by maximal electroshock (MES) method and pentylenetetrazol (PTZ) method. Statistical analysis was performed using one-way analysis of variance (ANOVA) followed by Dunnett«SQ»s test. At doses of 50, 100, and 200 mg/kg, HEJGL showed significant analgesic and anticonvulsant effects in experimental animals. In view of its analgesic and anticonvulsant activity, the JGL extract can be used in painful conditions as well as in seizure disorders.


How to cite this article:
Gupta RK, Reddy PS. Antinociceptive and anticonvulsant activities of hydroalcoholic extract of Jasminum grandiflorum (jasmine) leaves in experimental animals.Phcog Res 2013;5:286-290


How to cite this URL:
Gupta RK, Reddy PS. Antinociceptive and anticonvulsant activities of hydroalcoholic extract of Jasminum grandiflorum (jasmine) leaves in experimental animals. Phcog Res [serial online] 2013 [cited 2020 Nov 26 ];5:286-290
Available from: http://www.phcogres.com/article.asp?issn=0974-8490;year=2013;volume=5;issue=4;spage=286;epage=290;aulast=Gupta;type=0