Pharmacognosy Research

ORIGINAL ARTICLE
Year
: 2013  |  Volume : 5  |  Issue : 4  |  Page : 247--253

Antineoplastic potential of Bryophyllum pinnatum lam. on chemically induced hepatocarcinogenesis in rats


Muhammad Afzal1, Imran Kazmi2, Firoz Anwar2 
1 Department of Pharmacology, Pacific University, Udaipur, Rajasthan; Siddhartha Institute of Pharmacy, Dehradun, Uttarakhand, India
2 Department of Pharmacology, Pacific University, Udaipur, Rajasthan, India

Correspondence Address:
Imran Kazmi
Siddhartha Institute of Pharmacy, Near IT Park, Dehradun - 248 001, Uttarakhand
India

Background: Bryophyllum pinnatum Lam. used in folk medicine in tropical Africa, tropical America, India, China and Australia contains a wide range of active compounds, well known for their haemostatic and wound-healing properties. Objective: The present study was designed to evaluate the effect of Bryophyllum pinnatum Lam. on N-diethylnitrosamine (DENA)-induced hepatic injury in rats. Material and Methods: The aerial part of B. pinnatum aqueous and ethanolic extract was prepared in doses of 250 mg/kg and 500 mg/kg. Hepatic injury was induced by DENA. Acute toxicity was also carried out. Result: Treatment with different doses of ethanolic extract of B. Pinnatum (250 mg/kg, p.o.) was not significantly able to treat the liver injury induced by DENA, but 500 mg/kg dose of ethanolic extract of B. Pinnatum protects the liver slightly. Treatment with different doses of aqueous extract of B. Pinnatum (250 and 500 mg/kg, p.o.) significantly (P*<0.05; P**<0.01 and P***<0.001) treated the liver injury induced by DENA. Conclusion: It may be inferred from the present study that the hepatoprotective activities of the aqueous extract of B. Pinnatum leaves in DENA-induced hepatotoxicity may involve its antioxidant or oxidative free radical scavenging activities by alleviating lipid peroxidation through scavenging of free radicals, or by enhancing the activity of antioxidants.


How to cite this article:
Afzal M, Kazmi I, Anwar F. Antineoplastic potential of Bryophyllum pinnatum lam. on chemically induced hepatocarcinogenesis in rats.Phcog Res 2013;5:247-253


How to cite this URL:
Afzal M, Kazmi I, Anwar F. Antineoplastic potential of Bryophyllum pinnatum lam. on chemically induced hepatocarcinogenesis in rats. Phcog Res [serial online] 2013 [cited 2021 Apr 21 ];5:247-253
Available from: http://www.phcogres.com/article.asp?issn=0974-8490;year=2013;volume=5;issue=4;spage=247;epage=253;aulast=Afzal;type=0