Pharmacognosy Research

ORIGINAL ARTICLE
Year
: 2013  |  Volume : 5  |  Issue : 3  |  Page : 173--178

Anti-ulcer and ulcer healing potentials of Musa sapientum peel extract in the laboratory rodents


Samuel Adetunji Onasanwo1, Benjamin Obukowho Emikpe2, Austin Azubuike Ajah1, Taiwo Olayemi Elufioye3 
1 Department of Physiology, Faculty of Basic Medical Sciences, College of Medicine, Ibadan, Nigeria
2 Department of Veterinary Pathology, Faculty of Veterinary Medicine, Ibadan, Nigeria
3 Department of Pharmacognosy, Faculty of Pharmacy, University of Ibadan, Ibadan, Nigeria

Correspondence Address:
Samuel Adetunji Onasanwo
Department of Physiology, Faculty of Basic Medical Sciences, University of Ibadan
Nigeria

Background: This study investigated the anti-ulcer and ulcer healing potentials of the methanol extract of Musa sapientum peel in the laboratory rats. Materials and Methods: Methanol extract of the peels on Musa sapientum (MEMS) was evaluated for its anti-ulcer using alcohol-induced, aspirin-induced, and pyloric ligation-induced models, and for its ulcer healing employing acetic acid-induced ulcer models in rats. Results: The findings from this experiment showed that MEMS (50, 100 and 200 mg/kg, b.w.) anti-ulcer and ulcer healing activity (P ≤ 0.05) is dose-dependent. Also, MEMS exhibited healing of the ulcer base in all the treated groups when compared with the control group. Conclusion: The outcomes of this experiment revealed that the anti-ulcer effect of MEMS may be due to its anti-secretory and cyto-protective activity. The healing of the ulcer base might not be unconnected with basic fibroblast growth factors responsible for epithelial regeneration.


How to cite this article:
Onasanwo SA, Emikpe BO, Ajah AA, Elufioye TO. Anti-ulcer and ulcer healing potentials of Musa sapientum peel extract in the laboratory rodents.Phcog Res 2013;5:173-178


How to cite this URL:
Onasanwo SA, Emikpe BO, Ajah AA, Elufioye TO. Anti-ulcer and ulcer healing potentials of Musa sapientum peel extract in the laboratory rodents. Phcog Res [serial online] 2013 [cited 2021 Jun 15 ];5:173-178
Available from: http://www.phcogres.com/article.asp?issn=0974-8490;year=2013;volume=5;issue=3;spage=173;epage=178;aulast=Onasanwo;type=0